食蟹猴脑与结肠中寡聚化和磷酸化α-突触核蛋白的增龄性变化的相关性分析

发布时间：2018-05-19 00:06

本文选题：α-突触核蛋白 + 结肠　；参考：《首都医科大学学报》2017年06期

【摘要】：目的研究寡聚化和磷酸化α-突触核蛋白(α-synuclein,α-Syn)在食蟹猴结肠和脑中的增龄性变化及其相关性。方法ELISA方法检测寡聚化和磷酸化α-Syn在不同年龄段食蟹猴结肠与脑中不同部位含量的变化,分析结肠和脑中寡聚化和磷酸化α-Syn含量变化的相关性。结果寡聚化与磷酸化α-Syn含量随年龄增加而增加,其中老年猴与青年及中年猴比较,差异有统计学意义(P0.01)。结肠中的寡聚化和磷酸化α-Syn水平与颞叶、海马、纹状体和丘脑中的水平有相关性。结论食蟹猴结肠和脑中寡聚化和磷酸化α-Syn含量随老化而增加,结肠和脑中寡聚化和磷酸化α-Syn含量变化呈正相关。
[Abstract]:Objective to study the age-related changes of 伪 -synuclein (伪 -Synn) in colon and brain of crab monkey. Methods ELISA method was used to detect the changes of 伪 -Syn content in colon and brain of crab monkey in different ages, and the correlation between 伪 -Syn and oligomerization and phosphorylated 伪 -Syn in colon and brain were analyzed. Results the content of 伪 -Syn in oligomerization and phosphorylation increased with the increase of age. The difference of 伪 -Syn content between middle and aged monkeys was statistically significant compared with that of young and middle-aged monkeys (P 0.01). The levels of oligomerization and phosphorylation in colon were correlated with those in temporal lobe, hippocampus, striatum and thalamus. Conclusion the oligomerization and phosphorylation of 伪 -Syn in colon and brain increased with aging, and the changes of 伪 -Syn in colon and brain were positively correlated. Conclusion\;
【作者单位】：首都医科大学宣武医院神经生物学研究室北京市老年病医疗研究中心;首都医科大学帕金森病临床诊疗与研究中心;帕金森病北京市重点实验室和教育部神经变性病重点实验室;国家老年疾病临床医学研究中心;
【基金】：国家自然科学基金(81371200,81071014,81401042) 北京市医院管理局“使命”计划专项经费资助项目(SML20150803) 北京市科学技术委员会资助项目(Z161100005116011,Z171100000117013) 北京市卫生和计划生育委员会项目(PXM2017_026283_000002)~~
【分类号】：R742.5

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