多系统萎缩患者静息态下脑活动的局部一致性

发布时间：2018-05-23 09:26

  本文选题：多系统萎缩 + 功能磁共振　； 参考：《南京医科大学学报(自然科学版)》2017年04期

【摘要】：目的:采用静息态功能磁共振(resting state functional magnetic resonance image,rs-f MRI)方法探讨不同亚型多系统萎缩(multiple system atrophy,MSA)患者脑局部一致性(regional homogeneity,ReHo)的变化及其与临床症状严重程度的相关性。方法:对48例MSA患者(MSA-C型28例及MSA-P型20例)和27例健康对照进行rs-f MRI扫描,比较3组间ReHo的差异,采用简易精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)、统一的MSA评分量表(UMSARS)等评估临床症状,并分析MSA患者ReHo值与临床症状严重程度之间的关系。结果:(1)相对于对照组,MSA-C组双侧楔前叶、左侧海马、左侧枕中回、小脑蚓部Ⅴ~ⅥReHo增高,左侧小脑前/后叶ReHo减低;MSA-P组双侧丘脑、左侧尾状核、脑干、小脑蚓部ⅤReHo增高,左侧小脑前/后叶ReHo减低;相对于MSA-P组,MSA-C组左侧楔前叶、左侧海马、左侧颞中回ReHo增高,右侧枕中回ReHo减低。(2)MSA-C组双侧楔前叶与MoCA评分呈负相关,MSA-P组双侧丘脑与UMSARS-Ⅱ评分呈正相关。结论:静息态下MSA患者存在局部脑区的神经元活动一致性异常,这些脑区异常可能与MSA的病理机制有关。
[Abstract]:Objective: to investigate the changes of regional homogeneity in brain of patients with different subtypes of multiple system atrophy (system atrophy) by resting state functional magnetic resonance imageres-f MRIs and its correlation with the severity of clinical symptoms. Methods: rs-f MRI scans were performed in 48 MSA patients with MSA-C type and 20 patients with MSA-P type) and 27 healthy controls. The difference of ReHo among the three groups was compared. The clinical symptoms were evaluated with the mini-mental state scale (MMSE), the Montreal Cognitive Assessment scale (Montreal Cognitive Assessment scale) and the Unified MSA scale (UMSARS). The relationship between the ReHo value and the severity of clinical symptoms in patients with MSA was analyzed. Results compared with MSA-C group, the left hippocampus, left middle occipital gyrus, 鈪，

本文编号：1924170