基于脑体模的颅脑选择性制冷方式的实验评价

发布时间：2018-05-23 11:44

本文选题：颅脑亚低温 + 选择性制冷　；参考：《浙江大学》2014年硕士论文

【摘要】：颅脑亚低温治疗具有显著的神经保护疗效,虽然全身亚低温治疗得到了较多的临床应用,但是存在着冷却速度慢、会引发拮抗器官并发症等缺陷。选择性亚低温治疗可以克服这些不足,但是需要解决颅脑深部无损温度检测以及自动、精确的温度控制算法等问题。针对这些挑战,本文提出了一种基于颅脑物理模型的颅脑温度分布实测实验研究方法,并对选择性亚低温制冷方式进行了评价,有着重要的研究价值和实际意义。论文在分析了颅脑结构和生物热传导特性的基础上构建了用于颅脑仿真实验和检测系统评价的脑体模,并且在此基础上设计和搭建了针对脑体模的实时温度分布检测和选择性制冷的实验系统。定量测试表明该系统能够连续调节制冷液温度和流量、稳定测定和动态显示脑体模内部温度分布和变化过程,具备进行温度分布测量和选择性制冷方式评价的功能。运用提出的实验方法和检测控制系统对无内热源和有内热源两类脑体模进行了选择性制冷效果评价研究,通过分析脑体模内部监测点的温度信息及其变化规律,对颅脑温度特性和制冷效果进行了有效的实验评价。研究结果表明,相对于有损的血管内血液直接制冷方法,无损的颅脑外表面间接制冷方法的制冷深度和速度受到颅脑血液灌注率等影响因素的影响更大。虽然制冷效率不是最高,但是颅脑外表面间接制冷方法由于其无损、操作简单、安全更适用于临床医疗。与此相反,血管内血液直接制冷方法具有制冷效率高,速度更快更容易达到颅脑温度深部浅部均匀状态,但是受其有损和操作复杂等问题的影响目前更适用于临床医学研究。同时降温特性的分析表明了脑体模深部和浅表组织的温度具有一定的关系,有望通过浅表组织的温度估测深部组织的温度,实现低损甚至无损的脑温测量,以及对脑温的自动控制。
[Abstract]:The low - temperature treatment of craniocerebral hypothermia has remarkable nerve protection effect , although systemic hypothermia therapy has many clinical applications , but there is some defects such as slow cooling rate , which can lead to antagonistic organ complications , etc . The selective sub - hypothermia treatment can overcome these shortcomings . In view of these challenges , this paper presents a method for measuring the temperature distribution of craniocerebral deep brain and the automatic and accurate temperature control algorithm .

Based on the analysis of the characteristics of brain structure and biothermal conduction , the brain phantom used for brain simulation experiment and detection system evaluation was designed and constructed . The real - time temperature distribution and selective cooling of the brain phantom were designed and built . The quantitative test showed that the system can continuously adjust the temperature and flow of the refrigerating fluid , stabilize the measurement and dynamically display the temperature distribution and the change process of the brain phantom , and have the functions of temperature distribution measurement and selective cooling mode evaluation .

The results show that the direct refrigeration method is more suitable for clinical medical research by analyzing the temperature information and the changing law of the internal monitoring points of the brain phantom . The results show that the indirect refrigeration method of the external surface of the brain is more suitable for clinical medical research .
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R454.5;R742

【参考文献】