新生儿缺氧缺血性脑病血清中胰岛素样生长因子-1的水平变化及临床意义

发布时间：2018-05-23 11:15

本文选题：新生儿 + 缺氧缺血性脑病　；参考：《中国实用神经疾病杂志》2013年24期

【摘要】：目的动态观察新生儿血清胰岛素样生长因子-1(IGF-1)水平变化,探讨血清IGF-1在新生儿缺氧缺血性脑病(HIE)病情的早期诊断、程度判断的临床意义。方法选择我院2012-01—2012-12收住的HIE患儿62例为观察组(HIE组),并根据病情轻重分为轻度、中度、重度,以同期正常健康新生儿18例为对照组(正常组),观察2组血清IGF-1水平变化。结果 HIE组急性期血清IGF-1水平与正常组比较差异有统计学意义(P0.01),HIE组急性期与恢复期比较差异有统计学意义(P0.01),HIE组恢复期血清IGF-1水平与正常组比较差异无统计学意义(P0.05)。HIE组急性期轻度与中度、重度间IGF-1水平比较差异均有统计学意义(P0.01),而中、重度间比较差异无统计学意义(P0.05)。HIE组恢复期轻度与中度、重度间IGF-1水平比较差异均有统计学意义(P0.01),而中、重度间比较差异无统计学意义(P0.05)。结论监测血清IGF-1水平变化有助于临床对病情轻重的分度,对HIE诊断、治疗和预后判断具有指导作用。
[Abstract]:Objective to dynamically observe the changes of serum insulin like growth factor -1 (IGF-1) level in newborn infants, to explore the early diagnosis of serum IGF-1 in neonatal hypoxic ischemic encephalopathy (HIE), and to evaluate the clinical significance of the degree. Methods 62 children with HIE in our hospital, 2012-01 2012-12, were selected as the observation group (group HIE) and were divided into mild cases according to the severity of the disease. Moderate, severe, normal healthy newborn 18 cases as the control group (normal group), observe the changes in serum IGF-1 level in 2 groups. Results in group HIE, the level of serum IGF-1 in acute phase of group HIE was significantly different from that of normal group (P0.01), and there was a significant difference between the acute phase and the recovery period in group HIE (P0.01), and the level of serum IGF-1 in the HIE convalescence period and the positive group in group HIE. There was no significant difference in the difference between the normal group (P0.05) and the.HIE group in the acute period, and the difference in the level of IGF-1 was statistically significant (P0.01), but there was no significant difference between the severe and severe (P0.05) group.HIE (P0.05) in the group.HIE, and there was a significant difference between the severe and severe IGF-1 levels (P0.01). There was no significant difference in comparison (P0.05). Conclusion the change of serum IGF-1 level was helpful to the classification of the severity of the disease, and had a guiding role in the diagnosis, treatment and prognosis of HIE.
【作者单位】：新乡医学院;河南南阳市第一人民医院;
【分类号】：R722.1

【相似文献】