脑梗死患者颅内外动脉粥样硬化与T细胞亚群的相关性

发布时间：2018-05-28 03:41

本文选题：脑梗死 + 颅内外动脉粥样硬化　；参考：《中国动脉硬化杂志》2017年11期

【摘要】：目的探讨脑梗死患者颅内外动脉粥样硬化与外周血T细胞亚群的相关性。方法将脑梗死组180例脑梗死患者按类肝素药物治疗急性缺血性脑卒中试验(TOAST)亚型分类标准分为大动脉粥样硬化性脑梗死组(LAA组)、心源性栓塞组(CE组)、小动脉闭塞性脑梗死组(SAA组)、其他原因所致脑梗死(SOE组)组、不明原因脑梗死(SUE组);按头颈CT血管造影(CTA)颅内外动脉狭窄结果分为无狭窄组、单纯颅外动脉狭窄组、单纯颅内动脉狭窄组、颅内外动脉狭窄组,各狭窄组进一步按狭窄程度分为轻、中及重度狭窄组。同时选取健康体检者60例作为对照组。分别比较各组间血T细胞亚群水平。结果脑梗死组CD4+T细胞水平明显高于对照组,CD8+T细胞水平明显低于对照组(P0.05);LAA组和SAA组CD4+T细胞水平显著高于其他类型脑梗死组及对照组,而CD8+T细胞水平呈相反表现(P0.05);颅内外动脉狭窄严重程度与CD4+T细胞呈正相关,与CD8+T细胞呈负相关。无狭窄组CD4+T细胞水平低于各狭窄组,CD8+T细胞水平高于各狭窄组(P0.05),而各狭窄组间T细胞亚群差异无统计学意义。结论 CD4+T细胞和CD8+T细胞与脑梗死患者动脉粥样硬化密切相关,检测血T细胞亚群对颅内外动脉粥样硬化及其严重程度具有一定的预测价值。
[Abstract]:Objective to investigate the correlation between intracranial and extracranial atherosclerosis and T cell subsets in peripheral blood of patients with cerebral infarction. Methods 180 patients with cerebral infarction in cerebral infarction group were divided into two groups according to the subtype classification of heparin-like drug therapy in acute ischemic stroke test (TOAST): large artery atherosclerotic cerebral infarction group (ACI group), cardiac embolism group (CE group), arteriole occlusion group (CAO). Cerebral infarction group (SAA group, other causes of cerebral infarction) group (SOE group), According to the results of head and neck CT angiography (CTAA), the patients were divided into three groups: no stenosis group, simple extracranial artery stenosis group, simple intracranial artery stenosis group, and intracranial external artery stenosis group. Each stenosis group was further divided into light, moderate and severe stenosis groups according to the degree of stenosis. At the same time, 60 healthy persons were selected as control group. The levels of blood T cell subsets were compared in each group. Results the level of CD4 T cells in cerebral infarction group was significantly higher than that in control group (P 0.05) and SAA group (P 0.05). The level of CD4 T cell in cerebral infarction group was significantly higher than that in other cerebral infarction group and control group. However, the level of CD8 T cells was opposite to that of CD8 T cells, and the severity of intracranial and extracranial artery stenosis was positively correlated with CD4 T cells and negatively correlated with CD8 T cells. The level of CD4 T cells in no stenosis group was lower than that in each stenosis group and the level of CD8 T cell was higher than that in each stenosis group (P 0. 05), but there was no significant difference in T cell subsets among different stenosis groups. Conclusion CD4 T cells and CD8 T cells are closely related to atherosclerosis in patients with cerebral infarction. The detection of blood T cell subsets may be useful in predicting the severity and severity of intracranial and extracranial atherosclerosis.
【作者单位】：安徽医科大学第一附属医院神经内科;
【分类号】：R743.33

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