自身免疫性脑炎治疗进展

发布时间：2018-05-30 23:13

  本文选题：自身免疫性脑炎 + 免疫调节药物　； 参考：《解放军医学杂志》2017年04期

【摘要】：自身免疫性脑炎是机体免疫系统对神经元抗原成分产生异常免疫反应所致的中枢神经系统炎性疾病,通常被认为是非感染因素引起的可逆转性脑炎,其特征性临床表现包括急性或亚急性起病的认知功能障碍、癫痫发作及精神异常。随着相关抗体的陆续发现,各类临床综合征的总结提出,以及功能影像学工具的推广应用,自身免疫性脑炎的诊断流程日益规范。自身免疫性脑炎的治疗以免疫调节为主,主要包括激素、人免疫球蛋白、血浆置换及免疫抑制剂的应用,其他治疗手段包括相关肿瘤的切除、电休克疗法等。多数患者的临床症状经过积极治疗可获得实质性改善。本文主要对自身免疫性脑炎治疗的研究进展进行综述。
[Abstract]:Autoimmune encephalitis is an inflammatory disease of the central nervous system caused by the abnormal immune response of the immune system to the antigens of neurons. It is generally considered to be a reversible encephalitis caused by non-infectious factors. Its characteristic clinical manifestations include acute or subacute cognitive impairment, seizures and mental disorders. With the discovery of related antibodies, the summary of clinical syndrome and the application of functional imaging tools, the diagnosis process of autoimmune encephalitis is becoming more and more standardized. The treatment of autoimmune encephalitis mainly includes hormone, human immunoglobulin, plasma exchange and the application of immunosuppressant. Other treatment methods include tumor resection, electroshock therapy and so on. The clinical symptoms of most patients can be substantially improved after active treatment. This article reviews the progress in the treatment of autoimmune encephalitis.
【作者单位】： 解放军医学院;解放军总医院神经内科;
【基金】：全军医学科技“十二五”科研项目(CWS11J064)~~
【分类号】：R742.9
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本文编号：1957238