吸烟状态对氯吡格雷疗效的影响

发布时间：2018-06-04 18:00

本文选题：缺血性卒中 + 吸烟　；参考：《中风与神经疾病杂志》2017年04期

【摘要】：目的通过血栓弹力图检测,观察吸烟状态是否会对缺血性卒中患者的氯吡格雷疗效产生影响。方法回顾性连续纳入2013年1月-2014年10月首次发病的急性非心源性栓塞所致的缺血性脑血管病并接受氯吡格雷治疗的患者202例,分为吸烟组和不吸烟组。连续服用氯吡格雷每日75 mg,5 d后,抽取外周静脉血,用血栓弹力图仪测定氯吡格雷对血小板的抑制率。结果与非吸烟组相比,吸烟组患者氯吡格雷诱导的二磷酸腺苷抑制率更高(55.29%±25.92%vs 53.25%±27.02%,P=0.589),出现氯吡格雷反应低下(二磷酸腺苷抑制率30%)的患者比例更低(15.8%vs 19.5%,P=0.498),但差异无统计学意义。结论在非心源性栓塞的缺血性卒中患者中,吸烟有提高氯吡格雷反应性,增强其抗血小板聚集作用的趋势。但吸烟者中氯吡格雷治疗后血小板反应的变异性仍有待进一步研究证实。
[Abstract]:Objective to investigate the effect of smoking on clopidogrel in patients with ischemic stroke by thromboelastography. Methods 202 patients with ischemic cerebrovascular disease caused by acute non-cardiac embolism from January 2013 to October 2014 who were treated with clopidogrel were divided into smoking group and non-smoking group. After taking clopidogrel 75 mg / d for 5 days, peripheral venous blood was extracted and the platelet inhibition rate of clopidogrel was measured by thromboelastography. Results compared with non-smoking group, the inhibition rate of adenosine diphosphate induced by clopidogrel in smoking group was higher than that in non-smoking group. The inhibition rate of adenosine diphosphate induced by clopidogrel was 55.29% 卤25.92%vs 53.25% 卤27.02% 卤0.589%, and the proportion of patients with low clopidogrel reaction (adenosine diphosphate inhibition rate 30) was lower than that of non-smoking group, but there was no significant difference. Conclusion smoking has a tendency to increase clopidogrel reactivity and platelet aggregation in patients with non-cardiac embolism ischemic stroke. However, the variability of platelet reaction in smokers after clopidogrel treatment remains to be further studied.
【作者单位】：首都医科大学宣武医院神经内科;
【基金】：北京市科协金桥工程种子资金A类项目(ZZ15002)
【分类号】：R743.3

【相似文献】