左乙拉西坦对癫痫患儿性激素和甲状腺激素的影响

发布时间：2018-06-05 04:21

本文选题：癫痫 + 左乙拉西坦　；参考：《中国药房》2017年35期

【摘要】：目的:考察左乙拉西坦对癫痫患儿性激素和甲状腺激素的影响,并评价其安全性。方法:选择2013年7月-2015年2月南通大学附属医院(以下简称"我院")初诊为癫痫的患儿22例,设为观察组;选择同期于我院行健康体检的儿童17例,设为对照组。观察组患儿给予左乙拉西坦片,起始剂量为10 mg/kg,每1～2周增加10 mg/(kg·d)[目标剂量为30～40 mg/(kg·d)],疗程为12个月。观察对照组儿童用药前和观察组患儿用药前以及用药后3、6、12个月的性激素[促卵泡生成素、促黄体生成素、垂体泌乳素、孕酮、睾酮、雌二醇]和甲状腺激素[总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)]水平,记录观察组患儿不良反应发生情况。结果:用药前,两组受试者的性激素、甲状腺激素水平比较,差异均无统计学意义(P0.05)。用药后3、6、12个月,观察组患儿性激素水平与用药前比较,差异均无统计学意义(P0.05);用药后3、6个月,观察组患儿甲状腺激素水平与用药前比较,差异均无统计学意义(P0.05);用药后12个月,TT3、TT4、FT4、TSH水平与用药前比较,差异均无统计学意义(P0.05),而FT3水平较用药前显著升高,差异有统计学意义(P0.05)。观察组患儿中有2例发生不良反应(9.1%),未经特殊处理,其症状均于发生1～2周后消失。结论:左乙拉西坦用于治疗儿童癫痫,对患儿的性激素水平无明显影响,但可升高其FT3水平。
[Abstract]:Objective: to investigate the effect of levoethylacetam on sex hormone and thyroid hormone in epileptic children and to evaluate its safety. Methods: from July 2013 to February 2015, 22 children with epilepsy were selected from Nantong University affiliated Hospital (hereinafter referred to as "our hospital") as observation group, and 17 children who underwent physical examination in our hospital were selected as control group. The children in the observation group were given levoethylacetam tablets at the initial dose of 10 mg / kg for 10 mg/(kg / kg every 2 weeks [the target dose was 30 ~ 40 mg/(kg / d] and the course of treatment was 12 months. The sex hormones (follicle stimulating hormone, luteinizing hormone, pituitary prolactin, progesterone, testosterone) were observed in the control group and the control group. The levels of estradiol and thyroid hormone (total triiodothyronine TT3, total thyroxine TT4, free triiodothyronine FT 3, free thyroxine FT 4, TSH) were recorded. The adverse reactions of children in the observation group were recorded. Results: there was no significant difference in sex hormone and thyroid hormone levels between the two groups before medication (P 0.05). The levels of sex hormone in the observation group were not significantly different from those before the treatment, and the thyroid hormone levels in the observation group were compared with those before the treatment at 3 and 6 months after the administration of the drug, and there was no significant difference in the level of sex hormone between the observation group and the control group at 3 and 12 months after the treatment. There was no significant difference (P 0.05) between the two groups, but there was no significant difference in the level of TSH between the two groups 12 months after treatment. However, the level of FT3 was significantly higher than that before treatment (P 0.05). In the observation group, adverse reactions occurred in 2 cases. Without special treatment, the symptoms disappeared 12 weeks later. Conclusion: levoethylacetam has no effect on sex hormone level in children with epilepsy, but it can increase FT3 level.
【作者单位】：无锡市儿童医院儿科;南通大学附属医院儿科;
【分类号】：R742.1

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