血清高迁移率族蛋白B1与颈动脉易损斑块患者合并短暂性脑缺血发作的相关性研究

发布时间：2018-06-06 00:23

本文选题：颈动脉易损斑块 + 短暂性脑缺血发作　；参考：《中国实用神经疾病杂志》2016年24期

【摘要】：目的探讨血清高迁移率族蛋白B(HMGB1)与颈动脉易损斑块合并短暂性脑缺血发作(TIA)的相关性。方法本研究共纳入144例颈动脉易损斑块患者,根据是否合并TIA分为合并TIA组(A组,n=48)及未合并TIA(B组,n=96),另设颈动脉稳定斑块患者(C组,n=60)及正常健康人群组(D组,n=45)为对照组,采用酶联免疫吸附(ELISA)法测量各组血清高迁移率族蛋白B1水平。结果 A组血清HMGB1水平显著高于B组[(8.75±1.46)ng/mL vs(5.12±30.64)ng/mL],B组血清HMGB1水平显著高于C组[(5.12±30.64)ng/mL vs(2.35±0.42)ng/mL],上述3组血清HMGB1水平显著高于D组的(1.38±0.21)ng/mL,差异均有统计学意义(P0.05)。多元Logistic回归分析显示,高血清HMGB1水平与颈动脉易损斑块合并TIA呈独立相关(优势比2.374,95%可信区间1.264~3.982;P0.01)。结论血清高迁移率族蛋白B1水平的升高有助于评估颈动脉易损斑块患者发生TIA的风险。
[Abstract]:Objective to investigate the relationship between serum high mobility group protein (BHMGB1) and carotid plaque with transient ischemic attack (TIA). Methods in this study, 144 patients with carotid artery vulnerable plaque were divided into two groups according to whether they were complicated with TIA. They were divided into two groups: TIA group (n = 48) and group without TIA(B (n = 96). The patients with stable carotid plaque were divided into two groups: group C (n = 60) and group D (n = 45) as control group. The serum levels of high mobility group B 1 were measured by enzyme linked immunosorbent assay (Elisa). Results the level of serum HMGB1 in group A was significantly higher than that in group B [8.75 卤1.46)ng/mL vs(5.12 卤30.64)ng/mL] HMGB1 in group B was significantly higher than that in group C [5.12 卤30.64)ng/mL vs(2.35 卤0.42)ng/mL], and the level of serum HMGB1 in group A was significantly higher than that in group D (1.38 卤0.21ng / mL, P 0.05). Multiple Logistic regression analysis showed that there was an independent correlation between high serum HMGB1 level and carotid plaque complicated with TIA (odds ratio was 2.374% 95% CI 1.264 卤3.982% P 0.01). Conclusion the elevated level of serum high mobility group protein B1 is helpful to evaluate the risk of TIA in patients with carotid artery vulnerable plaque.
【作者单位】：福州神经精神病防治院;
【分类号】：R743.31

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