聚乳酸-羟基乙酸导管移植修复坐骨神经损伤后的力学特性分析

发布时间：2018-06-06 05:19

本文选题：神经再生 + 坐骨神经　；参考：《中国组织工程研究》2017年06期

【摘要】：背景:有关自体神经和聚乳酸-羟基乙酸导管移植修复坐骨神经损伤后的拉伸、应力松弛力学特性测试鲜有报道。目的:对比分析自体神经和聚乳酸-羟基乙酸导管移植修复坐骨神经损伤后的拉伸、应力松弛力学特性。方法:取死后24 h内的新鲜人尸体坐骨神经标本60条,加工成长35 mm试样,分为3组,正常对照组不做任何处理,人工导管移植组、自体神经移植组切断坐骨神经标本,形成20 mm缺损,分别以聚乳酸-羟基乙酸人工导管、自体神经吻接修复,3组均进行拉伸和应力松弛测试。结果与结论:1各组坐骨神经试样应力最初600 s下降较快,600 s后下降缓慢,7 200 s时应力松弛曲线接近水平,各组坐骨神经试样的应力松弛曲线为对数关系变化趋势;2自体神经移植组、人工导管移植组拉伸弹性限度载荷、弹性限度应力、最大载荷、最大应力、弹性限度应变、最大应变小于正常对照组(P0.05),人工导管移植组拉伸弹性限度载荷、弹性限度应力、最大载荷、最大应力、弹性限度应变、最大应变大于自体神经移植组(P0.05);3结果表明,聚乳酸-羟基乙酸人工导管具有很好的拉伸和应力松弛力学特性,符合坐骨神经损伤移植修复生物材料的拉伸力学特性和应力松弛力学特性要求。
[Abstract]:Background: the mechanical properties of stress relaxation in the repair of sciatic nerve injury by autogenous nerve and polylactic acid-glycolic acid catheter are rarely reported. Aim: to compare the tensile and stress relaxation properties of autogenous nerve and polylactic acid-glycolic acid catheter in repairing sciatic nerve injury. Methods: sixty sciatic nerve specimens from fresh human cadavers within 24 hours after death were collected and processed for 35 mm growth. They were divided into 3 groups: normal control group without any treatment, artificial conduit transplantation group and autogenous nerve transplantation group with sciatic nerve transection. A 20 mm defect was formed and the tensile and stress relaxation tests were performed in all the 3 groups treated with poly (lactic acid-glycolic acid) artificial catheter and autologous nerve anastomosis. Results and conclusion the stress relaxation curve of the sciatic nerve samples in the first 600 s decreased more rapidly than that in the first 600 s and then decreased slowly for 7 200 s in all groups, and the stress relaxation curve was close to the level. The stress relaxation curve of sciatic nerve samples in each group was a logarithmic change trend. The tension limit load, elastic limit stress, maximum load, maximum stress and elastic limit strain were obtained in autologous nerve transplantation group and artificial conduit transplantation group. The maximum strain was smaller than that of the normal control group (P 0.05). The results of tensile elastic limit load, elastic limit stress, maximum load, maximum stress, elastic limit strain and maximum strain in the artificial catheter transplantation group were higher than those in the autogenous nerve transplantation group (P 0.05). The polylactic acid-glycolic acid artificial conduit has good tensile and stress relaxation mechanical properties, which meets the requirements of tensile mechanical properties and stress relaxation mechanical properties of sciatic nerve injury and repair biomaterials.
【作者单位】：吉林大学第二医院骨科;吉林大学中日联谊医院眼科;吉林大学中日联谊医院超声科;吉林大学中日联谊医院疼痛科;吉林大学数学学院;
【基金】：吉林省科技发展基金项目(20116492):射频调控颈部神经治疗脑源性供血不足的临床研究~~
【分类号】：R318.08;R745.4

【相似文献】