急性脑梗死患者血清尿酸水平与脑微出血的相关性研究

发布时间：2018-06-06 06:43

本文选题：急性脑梗死 + 尿酸　；参考：《检验医学与临床》2016年23期

【摘要】：目的探讨急性脑梗死患者血清尿酸水平与脑微出血(CMB)的相关性。方法连续性收录铁岭市中心医院2013年1月至2015年9月收治的急性脑梗死患者180例,根据MRI结果分为CMB组(n=80)和非CMB组(n=100)。分析比较入院当天和出院时血尿酸水平与CMB的相关性。结果入院时CMB组患者尿酸水平(323.2±33.4)μmol/L,明显高于非CMB患者的(284.2±54.8)μmol/L,差异有统计学意义(P0.05);CMB重度亚组患者尿酸水平(229.1±32.5)μmol/L,明显高于轻度亚组患者的(217.5±30.1)μmol/L,差异有统计学意义(P0.05)。对于CMB诊断价值可见,入院时尿酸的受试者工作特征曲线下面积(AUC)为0.832,cut off为279.2,敏感度为84.3%,特异性为74.9%。出院时尿酸的AUC为0.759,cut off为266.3,敏感度为77.8%,特异性为77.2%。入院时尿酸(r=0.719,P0.05)和出院时尿酸(r=0.689,P0.05)水平与CMB呈正相关。结论急性脑梗死患者血尿酸水平与CMB密切相关,是诊断CMB的潜在生物学标记物。
[Abstract]:Objective to investigate the correlation between serum uric acid level and cerebral microhemorrhage (CMB) in patients with acute cerebral infarction. Methods 180 patients with acute cerebral infarction admitted to Tieling Central Hospital from January 2013 to September 2015 were divided into CMB group (n = 80) and non-CMB group (n = 100) according to the results of MRI. To analyze and compare the correlation between serum uric acid level and CMB on admission day and discharge. Results the uric acid level in CMB group was 323.2 卤33.4 渭 mol / L at admission, which was significantly higher than that in non-CMB group (284.2 卤54.8) 渭 mol / L, the difference was statistically significant (P 0.05 卤32.5) 渭 mol / L, and was significantly higher than that in mild subgroup (217.5 卤30.1) 渭 mol / L (P 0.05). For the diagnostic value of CMB, the area under the operating characteristic curve was 0.832 cut off was 279.2, sensitivity was 84.3, specificity was 74.9%. At discharge, the AUC of uric acid was 0.759tcut off was 266.3, the sensitivity was 77.8, the specificity was 77.2. The levels of uric acid on admission and discharge were positively correlated with CMB. Conclusion the level of uric acid in patients with acute cerebral infarction is closely related to CMB and is a potential biological marker for the diagnosis of CMB.
【作者单位】：辽宁省铁岭市中心医院神经外科一病房;
【分类号】：R743.33;R446.1

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