生物碱类磷酸二酯酶抑制剂治疗帕金森疾病可行性探讨

发布时间：2018-06-09 05:45

本文选题：帕金森病 + 磷酸二酯酶　；参考：《中国药理学与毒理学杂志》2017年05期

【摘要】：帕金森疾病是一种常见的与年龄相关的神经退行性疾病,随年龄增长,发病几率增大,多发病于中老年人群中,其病理特征主要是纹状体区的多巴胺含量减少,发病机制复杂,至今尚不明确。目前,帕金森的治疗以维持多巴胺和乙酰胆碱平衡为主要治疗手段。治疗帕金森病的主要有多巴胺能药和抗胆碱药。但是副作用较大,且只能缓解症状而不能阻止神经退化。近年来的研究发现磷酸二酯酶家族生理作用广泛,得到越来越多学者的关注。其中磷酸二酯酶1中的磷酸二酯酶1B参与神经系统的多项生理活动,有多种中药提取物对其具有抑制作用,磷酸二酯酶1B抑制剂对认知功能障碍有一定的改善作用,并在临床用于帕金森病的治疗。中药治疗帕金森可弥补西药治疗的缺陷,具有毒副作用小,疗效持久的特点,是帕金森药物治疗的研究热点。中药治疗具有明显的优势和一定的发展前景,本文根据近年文献综述生物碱类中药对帕金森疾病治疗的可行性。
[Abstract]:Parkinson's disease is a common age-related neurodegenerative disease. The incidence of Parkinson's disease increases with age. The pathological features of Parkinson's disease are the decrease of dopamine in the striatum and the complicated pathogenesis. It is not clear yet. At present, Parkinson's treatment is to maintain dopamine and acetylcholine balance as the main treatment. The main treatments for Parkinson's disease are dopaminergic and anticholinergic drugs. But the side effect is big, and can alleviate symptom only but cannot prevent nerve degeneration. In recent years, researchers have found that phosphodiesterase family has a wide range of physiological functions, and has attracted more and more attention. Phosphodiesterase 1B in phosphodiesterase 1 is involved in many physiological activities of the nervous system, and some traditional Chinese medicine extracts have inhibitory effects on it, and phosphodiesterase 1B inhibitor can improve cognitive dysfunction to some extent. And used in clinical treatment of Parkinson's disease. Traditional Chinese medicine treatment of Parkinson's disease can make up for the defect of western medicine treatment, it has the characteristics of little side effect and lasting curative effect, so it is the research hotspot of Parkinson's drug therapy. Chinese medicine therapy has obvious advantages and certain development prospects. This paper reviews the feasibility of alkaloid Chinese medicine in the treatment of Parkinson's disease according to the literature in recent years.
【作者单位】：河北北方学院;
【分类号】：R742.5

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