血清促血管生成素水平在动脉瘤性蛛网膜下腔出血患者预后评估中的应用

发布时间：2018-06-10 13:22

本文选题：促血管生成素 + 动脉瘤性蛛网膜下腔出血　；参考：《东南大学学报(医学版)》2017年01期

【摘要】：目的:观察动脉瘤性蛛网膜下腔出血(a SAH)患者血清促血管生成素(Ang)水平、特异性受体Tie-2水平及其变化趋势,探讨Ang在a SAH患者预后评估中的应用价值。方法:收集111例a SAH患者作为研究对象,分别于发病后8、24、72 h检测血清Ang-1、Ang-2、Tie-2水平,并选择120例同期健康成年人作为对照,比较不同预后a SAH患者血清Ang水平及变化趋势,分析血清Ang水平与患者预后结局之间的关系。结果:Ang-1水平和Ang-1/Ang-2值在发病后8 h内已显著高于健康对照组水平,差异均有统计学意义(P0.05)。动脉瘤性蛛网膜下腔出血(a SAH)后8、24和72 h a SAH血清Ang-1表达水平预后良好组均高于预后不良组;a SAH后72 h血清Ang-2水平高于预后不良组,a SAH后24 h特异性受体Tie-2水平高于预后不良组,差异均有统计学意义(P0.05)。多因素Logistic回归分析显示,a SAH发病后8、24和72 h血清Ang-1表达水平和a SAH后24 h特异性受体Tie-2水平是a SAH患者预后的影响因素。结论:a SAH患者血清Ang-1水平变化趋势与预后情况呈正相关,Ang-1可以作为判定a SAH预后的重要生物标志物之一。
[Abstract]:Objective: to observe the level of serum angiopoietin (Ang) and the level of specific receptor (Tie-2) in patients with aneurysm subarachnoid hemorrhage (SAH), and to explore the value of Ang in evaluating the prognosis of patients with SAH. Methods: 111 patients with aSAH were collected as study subjects. The serum levels of Ang-1 and Ang-2 tie-2 were measured at 82472 hours after onset, and 120 healthy adults were selected as controls to compare the serum Ang levels and their changing trends in patients with different prognosis. To analyze the relationship between serum Ang level and prognosis. Results the levels of Ang-1 and Ang-1/Ang-2 were significantly higher than those in the healthy control group within 8 hours after the onset of the disease, and the differences were statistically significant (P 0.05). The level of serum Ang-1 expression in patients with good prognosis was higher than that in patients with poor prognosis at 72 h after SAH. The level of serum Ang-2 was higher than that of specific receptor Tie-2 at 24 h after SAH in patients with poor prognosis. Higher than those with poor prognosis, The difference was statistically significant (P 0.05). Multivariate logistic regression analysis showed that the expression of serum Ang-1 at 8h and 72h after the onset of ASAH and the level of specific receptor Tie-2 at 24 h after aSAH were the prognostic factors of patients with aSAH. Conclusion there is a positive correlation between the change trend of serum Ang-1 level and prognosis in the patients with Asah. Ang-1 may be one of the important biomarkers for judging the prognosis of ASAH.
【作者单位】：第三军医大学新桥医院神经外科;泸州市合江县人民医院康复科;
【基金】：国家自然科学基金资助项目(81301639)
【分类号】：R743.35

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