尤瑞克林对大鼠局灶性脑缺血再灌注损伤后炎性反应的影响

发布时间：2018-06-10 15:35

本文选题：脑缺血 + 尤瑞克林　；参考：《中风与神经疾病杂志》2017年03期

【摘要】：目的研究尤瑞克林对大鼠局灶性脑缺血再灌注损伤后炎性反应的影响。方法将90只SD大鼠随机分为3组:假手术组,对照组,治疗组。采用线栓法建立大鼠大脑中动脉闭塞再灌注模型,缺血2 h后,拔出线栓,恢复灌注24 h,观察大鼠神经功能缺损症状、脑梗死体积、脑组织中白细胞浸润、MPO活性、IL-1和ICAM-1的表达。结果 (1)假手术组大鼠在神经功能缺损评分、脑梗死体积均低于对照组,有显著的统计学差异(P0.01);脑组织中白细胞浸润程度、髓过氧化物酶(MPO)活性、ICAM-1和IL-1的表达均较对照组低,统计学差异明显(P0.01);(2)治疗组与对照组相比,大鼠的神经功能缺损评分低、脑梗死体积小,有显著统计学差异(P0.01);白细胞浸润程度、MPO活性、ICAM-1和IL-1的表达均较对照组减少(P0.01)。结论尤瑞克林可通过抑制大鼠脑缺血再灌注损伤后的炎性反应来实现其神经保护作用。
[Abstract]:Objective to study the effect of eurexine on inflammatory response after focal cerebral ischemia reperfusion injury in rats. Methods 90 SD rats were randomly divided into three groups: sham operation group, control group and treatment group. The rat model of middle cerebral artery occlusion and reperfusion was established by the method of thread occlusion. After 2 hours of ischemia, the rat middle cerebral artery occlusion (MCAO) reperfusion model was established. After 2 hours of ischemia, the nerve function defect symptom, the volume of cerebral infarction and the expression of IL-1 and ICAM-1 were observed. Results (1) the neurological deficit score and cerebral infarction volume in sham operation group were significantly lower than those in control group (P 0.01), and the expression of ICAM-1 and IL-1 in brain tissue was lower than that in control group, such as the degree of leukocyte infiltration and the activity of myeloperoxidase (MPO). Compared with the control group, the neurological deficit score of the treatment group was lower, the volume of cerebral infarction was small, there was significant difference (P 0.01), and the expression of ICAM-1 and IL-1 in the leucocyte infiltration degree and MPO activity were lower than that in the control group (P 0.01), and the expression of ICAM-1 and IL-1 in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion Urestrin can protect the brain by inhibiting the inflammatory response after cerebral ischemia-reperfusion injury in rats.
【作者单位】：陕西省人民医院神经内一科;
【分类号】：R743.3

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