缺血性卒中后血管性痴呆的MRI特点及相关危险因素分析

发布时间：2018-06-15 08:06

本文选题：血管性痴呆 + MRI　；参考：《宁夏医科大学》2014年硕士论文

【摘要】：目的本研究旨在通过分析缺血性卒中血管性痴呆的头颅MRI特点及相关危险因素，探讨其与VD发病的关系。方法筛选2012年1月—2013年7月在宁夏回族自治区人民医院神经内科住院的脑梗死后VD患者51例为VD组，诊断符合2002年中华医学会神经病学分会血管性痴呆诊断标准。同期选择脑梗死后非VD患者48例为非VD组(对照组)。99例脑卒中患者均于卒中后3个月内采用简易精神量表(MMSE)、HIS量表和蒙特利尔认知评估量表(MoCA)对其进行认知功能评定。比较分析VD组和非VD组患者的头颅MRI特点及相关危险因素。结果 1.VD组中额叶皮层的梗死发生率明显高于非VD组(X2=6.10，P0.05)；VD组中皮层下额叶的梗死发生率明显高于非VD组(X2=4.45，，P0.05)；VD组中内囊的梗死发生率明显高于非VD组(X2=3.96，P0.05)；VD组中丘脑的梗死发生率明显高于非VD组(X2=4.78，P0.05)。 2.VD组大梗死发生率明显高于非VD组(X2=9.11，P0.05)；VD组中梗死发生率明显高于非VD组(X2=5.58，P0.05)。 3.VD组吸烟发生率明显高于非VD组(X2=12.41，P0.05)；VD组高血压发生率明显高于非VD组(X2=4.50，P0.05)；VD组糖尿病发生率明显高于非VD组(X2=5.619,P0.05)。经多因素回归分析进一步分析发现吸烟、高血压、糖尿病与VD的发生相关。 4.VD组年龄、冠心病、高脂血症与非VD组相比，差异无统计学意义(P0.05)。结论 1.额叶皮层、皮层下额叶、内囊和丘脑的梗死更易导致VD的发生。 2.大梗死、中梗死比腔隙性梗死易导致VD发生。 3.吸烟、高血压、糖尿病与VD的发生相关，年龄、冠心病、高脂血症与VD发生的关系不明显。
[Abstract]:Objective to investigate the relationship between cerebral MRI features and related risk factors of ischemic stroke vascular dementia (VD). Methods from January 2012 to July 2013, 51 patients with VD after cerebral infarction in Department of Neurology, people's Hospital of Ningxia Hui Autonomous region were selected as VD group. The diagnosis was in accordance with the diagnostic criteria of vascular dementia in the Neurology Branch of the Chinese Medical Association in 2002. At the same time, 48 patients with non-VD after cerebral infarction were selected as non-VD group (control group, n = 99). The cognitive function was evaluated by MMSE / his scale and Montreal Cognitive Assessment scale (MoCA) within 3 months after stroke. The cranial MRI features and related risk factors of VD and non-VD patients were compared and analyzed. Results 1. The incidence of infarct in frontal cortex in VD group was significantly higher than that in non-VD group (X _ 2X _ (6.10) P _ (0.05) P _ (0.05) and non-VD group (P _ (4.45) P _ (0.05) and the incidence of infarction in internal capsule in VD group was significantly higher than that in non-VD group (X _ 23.96 P _ 0.05). The incidence of thalamus infarction in VD group was significantly higher than that in non-VD group (P 0.05). 2. The incidence of large infarction in VD group was significantly higher than that in non-VD group (X29.11) P0.05 (P 0.05). 3. The incidence of smoking in VD group was significantly higher than that in non-VD group (P 0.05). The incidence of hypertension in VD group was higher than that in non-VD group. Multivariate regression analysis showed that smoking, hypertension and diabetes were correlated with VD. 4. There was no significant difference in age, coronary heart disease, hyperlipidemia and non-VD between VD group and non-VD group (P 0.05). Conclusion 1. The infarction of frontal cortex, subcortical frontal lobe, internal capsule and thalamus is more likely to cause VD. 2. 2. Large infarction, middle infarction is more likely to lead to VD than lacunar infarction. 3. 3. Smoking, hypertension and diabetes were associated with VD. Age, coronary heart disease, hyperlipidemia were not associated with VD.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3

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