丘脑底核电刺激术治疗帕金森病患者术后疗效及认知功能评价

发布时间：2018-06-15 14:16

本文选题：丘脑底核电刺激术 + 帕金森病　；参考：《天津医科大学》2017年硕士论文

【摘要】：目的探讨丘脑底核电刺激术(subthalamic nucleus stimulation,STN-DBS)治疗帕金森病(Parkinson's disease,PD)患者术后疗效及认知功能改变。方法13例帕金森病患者,以术前症状情况作为对比基准线,记录患者统一帕金森评定量表(unified Parkinson's disease rating scale,UPDRS)评分和蒙特利尔认知评估量表(Montreal cognitive assessment scale,Mo CA)评分。行双侧丘脑底核电刺激手术,术后定期随访,记录术后1个月(脑深部电刺激系统开机)、3个月、6个月的UPDRS和Mo CA评分,对比分析STN-DBS手术效果。结果13例帕金森病患者双侧STN-DBS术后1月,脑深部电刺激系统开机,UPDRSII(日常生活活动)评分药物开/关期分别改善24.7%和27.5%,UPDRSIII(运动检查)评分药物开/关期分别改善25.8%和21.5%,Mo CA评分改善为㧟0.8%,术后3月UPDRSII评分药物开/关期分别改善32.4%和34.2%,UPDRSIII评分药物开/关期分别改善53.1%和47.0%,Mo CA评分改善为1.3%,术后6月UPDRSII评分药物开/关期分别改善40.2%和40.0%,UPDRSIII评分药物开/关期分别改善57.4%和47.9%,Mo CA评分改善为0.3%。结论丘脑底核电刺激术对于帕金森病患者的日常生活活动和运动症状改善有效,对于患者的认知症状改善无明显效果。
[Abstract]:Objective to investigate the effect and cognitive function of subthalamic nucleus stimulation (STN-DBS) in the treatment of Parkinson's disease (PD). Methods Thirteen patients with Parkinson's disease were enrolled in this study. The preoperative symptoms were used as the baseline. The unified Parkinson's disease rating scale (UPD RS) and Montreal cognitive assessment scale (Montreal cognitive assessment scale CAMo) were recorded. Bilateral subthalamic nuclear stimulation was performed and followed up regularly. The UPDRS and Mo CA scores were recorded 1 month after operation (the deep brain stimulation system was switched on, 3 months, 6 months), and the results of STN-DBS operation were compared and analyzed. Results one month after operation, 13 patients with Parkinson's disease underwent bilateral STN-DBS. The opening / closing period of the drug was improved by 24.7% and 27.5%, respectively. The opening / closing period of the drug was improved by 25.8% and 21.5Mo / CA, respectively. The score of UPDRSII was improved to 0.8% 3 months after operation. The opening / closing period of UPDRSIII was improved by 53.1% and that of Mo-Mo by 47.0% by 1.3.The opening / closing period of UPDRSII was improved by 40.2% and that of UPDRSIII was improved by 47.2% and 47.9MoCA by 0.33% respectively at 6 months after operation. Conclusion Subthalamic nuclear stimulation is effective in improving daily life and motor symptoms in patients with Parkinson's disease, but not in cognitive symptoms.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R742.5

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