偏头痛家族聚集性患者临床特点及其一级亲属患病风险因素分析

发布时间：2018-06-16 06:15

  本文选题：偏头痛 + 遗传　； 参考：《中国神经精神疾病杂志》2017年06期

【摘要】：目的观察偏头痛家族聚集性患者的临床特征,分析其一级亲属的患病风险因素。方法收集资料完整的偏头痛患者72例,根据有无偏头痛家族史分为两组,有偏头痛家族史组及无偏头痛家族史组。利用问卷采集两组患者临床资料,单因素分析筛选出有统计学意义的变量后进行多因素logistic回归分析其一级亲属患病的危险因素。结果 72例中至少有1名一级亲属患有偏头痛者37例,家族史阳性率为51.4%。与家族史阴性的偏头痛先证者比较,家族史阳性的先证者在性别(P=0.675)、年龄(P=0.598)、病程(P=0.419)、先兆(P=0.669)、头痛程度(P=0.837)、发作频率(P=0.465)及头痛伴随症状、头痛部位、头痛性质方面差异无统计学意义;与家族史阴性的头痛先证者比较,家族史阳性的先证者在起病年龄早(16岁)方面的差异(48.6%vs.22.9%,χ~2=5.186,P=0.023)及在头痛发作持续时间长(≥24 h)方面的差异(35.1%vs.14.3%,χ~2=4.170,P=0.041)有统计学意义(P0.05)。多因素回归发现,发病年龄早(OR=2.986,95%CI:1.621~5.503)、头痛发作持续时间长(OR=2.320,95%CI:1.219~4.415)的先证者,其一级亲属患病风险高(P0.05)。结论起病年龄早及头痛持续时间长的偏头痛患者,其一级亲属患偏头痛的风险更高。
[Abstract]:Objective to observe the clinical characteristics of migraine family cluster patients and analyze the risk factors of their first degree relatives. Methods 72 cases of migraine with complete data were divided into two groups according to the family history of migraine: the group with family history of migraine and the group without family history of migraine. The clinical data of two groups of patients were collected by questionnaire and the risk factors of first-degree relatives were selected by univariate analysis and multivariate logistic regression analysis. Results among 72 cases, at least one first-degree relative had migraine in 37 cases, and the positive rate of family history was 51.4. Compared with the migraine proband with negative family history, the patients with positive family history had no significant difference in sex (P < 0. 675), age (P = 0. 598), course of disease (P = 0. 419), omen (P = 0. 669), degree of headache (P = 0. 837), frequency of attack (P = 0. 465) and accompanied symptoms of headache, headache location and headache nature. Compared with those with negative family history, there were significant differences in the onset age of headache (48.6vs.22.9V) and the longer duration of headache (鈮，

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