血浆HGF、TNF-α、IL-10的差异与青年脑梗死患者预后的相关性的研究

发布时间：2018-06-17 13:52

本文选题：青年脑梗死 + 肝细胞生长因子　；参考：《中风与神经疾病杂志》2017年12期

【摘要】：目的探讨血浆HGF、TNF-α、IL-10的差异与青年脑梗死患者预后的相关性。方法选取我院2015年3月-2016年9月收治的100例青年脑梗死患者作为病例组进行回顾性分析。同时选取我院正常健康体检人员100例作为对照组,观察入院时青年脑梗死患者不同预后组之间及与健康体检组血浆肝细胞生长因子(hepatocyte growth factor,HGF)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、血清白细胞介素10(interleukin 10,IL-10)的浓度差异。并对脑梗死的危险因素如性别、年龄、高血压、吸烟、高血糖、高血脂、高同型半胱氨酸、酗酒、体重指数等因素进行Logistic回归分析。结果病例组入院时血浆HGF、TNF-α的浓度明显高于对照组,而血浆IL-10的浓度明显低于对照组,差异有统计学意义(P0.05);且预后越差组血浆HGF、TNF-α的浓度越高,IL-10的浓度越低,差异有统计学意义(P0.05)。通过Logistic回归分析显示高血压、吸烟、高血糖、高血脂、高同型半胱氨酸、酗酒、体重指数是青年脑梗死发病的危险因素(P0.05),而年龄、性别不是青年脑梗死的危险因素(P0.05)。结论血浆中HGF、TNF-α浓度与青年脑梗死患者预后呈负相关,而血浆中IL-10浓度则与青年脑梗死患者预后呈正相关。并预测对青年脑梗死患者血浆中HGF、TNF-α、IL-10浓度的监测可能有助于患者预后的预判断。
[Abstract]:Objective to investigate the relationship between plasma HGF- TNF- 伪 IL-10 and prognosis in young patients with cerebral infarction. Methods 100 young patients with cerebral infarction from March 2015 to September 2016 were retrospectively analyzed. At the same time, 100 healthy people in our hospital were selected as the control group. The plasma levels of hepatocyte growth factor (HGF), tumor necrosis factor- 伪 (TNF- 伪) and serum interleukin-10 (IL-10) in young patients with cerebral infarction were observed. Logistic regression analysis was performed on the risk factors of cerebral infarction such as sex, age, hypertension, smoking, hyperglycemia, hyperlipidemia, hyperhomocysteine, alcoholism and body mass index. Results the concentration of plasma HGF- TNF- 伪 was significantly higher than that of control group at admission, while the concentration of plasma IL-10 was significantly lower than that of control group (P 0.05), and the higher the concentration of HGF- TNF- 伪 in patients with worse prognosis was, the lower the concentration of IL-10 was (P 0.05). Logistic regression analysis showed that hypertension, smoking, hyperglycemia, hyperlipidemia, hyperhomocysteine, alcoholism and body mass index were the risk factors of cerebral infarction in young people (P 0.05), but age and sex were not the risk factors of young cerebral infarction (P 0.05). Conclusion the concentration of HGF- TNF- 伪 in plasma is negatively correlated with the prognosis of young patients with cerebral infarction, while the concentration of IL-10 in plasma is positively correlated with the prognosis of young patients with cerebral infarction. It was predicted that the monitoring of plasma HGF- TNF- 伪 -IL-10 level in young patients with cerebral infarction might be helpful to predict the prognosis of the patients.
【作者单位】：安徽医科大学第一附属医院神经内科;安徽省六安市第二人民医院;
【分类号】：R743.3

【相似文献】