急性脑梗死合并高同型半胱氨酸血症患者阿司匹林抵抗及相关因素分析

发布时间：2018-06-17 16:46

  本文选题：脑梗死 + 高同型半胱氨酸　； 参考：《脑与神经疾病杂志》2016年12期

【摘要】：目的观察急性脑梗死(ACI)患者合并高同型半胱氨酸血症(Hhcy)阿司匹林抵抗(AR)发生情况及相关因素。方法 2014年9月—2015年12月本院神经内科收治的急性脑梗死(ACI)患者146例为研究对象,根据同型半胱氨酸(Hcy)水平分为两组:Hhcy组(观察组)78例,非Hhcy组(对照组)68例,入院后两组均服阿司匹林100mg.d~(-1),连服1个月后,检测血常规、凝血常规和血小板聚集率,进行阿司匹林的疗效评价,AR定义为花生四烯酸诱导的血小板聚集率≥20%。结果 Hhcy组AR发生率为21.8%,明显高于非Hhcy组8.8%,两者相比差异有统计学意义(P0.05)。Logistic回归分析显示,Hhcy是发生AR的独立危险因素(β=-0.58,P0.01)。结论 ACI患者合并Hhcy的AR发生率明显增加,Hhcy是ACI患者发生AR的重要危险因素。临床工作中应给予充分重视,积极检测血清Hcy水平,积极监测血小板聚集率,预测AR,避免或延缓血栓性疾病的发生。
[Abstract]:Objective to observe the incidence and related factors of aspirin resistance (ARL) in patients with acute cerebral infarction (ACI) complicated with hyperhomocysteinemia. Methods from September 2014 to December 2015, 146 patients with acute cerebral infarction (ACI) treated in neurology department of our hospital were divided into two groups according to the level of homocysteine Hcycy (observation group 78 cases, non-HHcy group 68 cases, control group 68 cases). After admission, both groups were given 100 mg 路d ~ (-1) of aspirin. After taking aspirin for one month, blood routine examination, blood coagulation test and platelet aggregation rate were measured. The evaluation of the curative effect of aspirin was as follows: arachidonic acid-induced platelet aggregation rate 鈮，

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