转基因治疗根性撕脱以及脊髓损伤的研究进展（英文）

发布时间：2018-06-18 01:28

本文选题：骨髓损伤 + 臂丛神经根性撕脱伤　；参考：《暨南大学学报(自然科学与医学版)》2017年01期

【摘要】：根性撕脱伤和脊髓损伤是临床上非常重要的疾病,临床治疗方法很多,但难以成功治愈根性撕脱和脊髓损伤引起的瘫痪或慢性疼痛.基因治疗有可能为有效地治疗根性撕脱伤和脊髓损伤,并减轻对病人、家庭、医疗机构和世界经济的影响.癌症的治疗中基因治疗已解决了临床许多挑战性的问题,靶点基因的脊髓损伤研究从实验室走向临床.本综述从臂丛神经撕脱伤和脊髓损伤相关的血脊髓屏障的解剖和病理表现,脊髓损伤和根性撕脱伤基因治疗的种类,以及治疗脊髓损伤活体动物应用到的基因转运载体的种类,重点阐述病毒和非病毒载体转基因治疗在脊髓的转运路径.靶向脊髓的基因治疗已有很长时间,但仍然有问题没有解决,尤其是如何有效地转导病毒载体入在体动物的神经元仍未清楚.在病毒载体的安全性和设计上的问题未解决之前,临床治疗尚需进一步研究.
[Abstract]:Root avulsion and spinal cord injury are very important diseases in clinic. There are many clinical treatments, but it is difficult to cure paralysis or chronic pain caused by root avulsion and spinal cord injury. Gene therapy is likely to effectively treat root avulsion and spinal cord injury and mitigate the impact on patients, families, medical institutions and the world economy. Gene therapy has solved many challenging clinical problems in the treatment of cancer. The research of target gene spinal cord injury has moved from laboratory to clinic. This review reviews the anatomical and pathological features of the blood-spinal cord barrier associated with brachial plexus avulsion and spinal cord injury, the types of gene therapy for spinal cord injury and root avulsion, and the types of gene transport vectors used in the treatment of spinal cord injury in vivo. Focus on viral and non-viral vector translocation in the spinal cord. Gene therapy targeting the spinal cord has been for a long time, but there are still some problems, especially how to effectively transfer the virus vector into the neurons in vivo remains unclear. Clinical treatment needs further study before the safety and design of virus vectors are resolved.
【作者单位】：中山大学中山医学院解剖教研室;
【基金】：国家自然基金项目(31471030) 广东省科学基金项目(2014A020212070,2015A03011014) 广东省科学技术项目(201510010208)~~
【分类号】：R651.2

【参考文献】