同型半胱氨酸浓度及MTHFR基因多态性与缺血性脑卒中的相关性

发布时间：2018-06-18 02:36

本文选题：缺血性脑卒中 + 同型半胱氨酸　；参考：《中国实用神经疾病杂志》2014年17期

【摘要】：目的研究血浆同型半胱氨酸(Hcy)浓度及其代谢酶N5,N10-亚甲基四氢叶酸还原酶(MTHFR)基因多态性与缺血性脑卒中(IS)的关联。方法分别测定85例IS患者和82例对照者血浆Hcy浓度、叶酸、维生素B12水平及MTHFR基因多态性。结果 IS组血浆Hcy浓度显著高于对照组高Hcy血症所占比例高于对照组,差异有统计学意义(P0.05);IS组叶酸、维生素B12水平显著低于对照组;2组Hcy浓度与叶酸、维生素B12水平均呈负相关;MTHFR基因TT纯合子组血浆Hcy水平显著高于CT杂合子组及CC纯合子组;CT杂合子组和CC纯合子组间血浆Hcy浓度亦有显著性差异;MTHFR基因TT纯合子在IS的分布频率显著高于对照组;IS组MTHFR基因T、C等位基因频率分别为57.65%、42.35%,对照组为38.41%、61.59%,2组比较有显著性差异。结论血浆Hcy浓度增高是IS的危险因素之一;Hcy浓度与叶酸、维生素B12水平呈负相关,叶酸、维生素B12缺乏可能是导致血浆Hcy增高的重要原因;MTHFR基因突变很可能是血浆Hcy升高的主要影响因素;MTHFR基因C677T突变可能与IS的易感性密切相关。
[Abstract]:Objective to study the association between plasma homocysteine (Hcyn) concentration and its metabolic enzyme N5N 10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and ischemic stroke (ISI). Methods Plasma Hcy concentration, folic acid, vitamin B12 level and MTHFR gene polymorphism were measured in 85 patients with is and 82 controls. Results the plasma Hcy concentration in is group was significantly higher than that in control group. The difference was statistically significant (P 0.05). The level of vitamin B12 in is group was significantly lower than that in control group (P 0.05). The plasma Hcy levels in TT homozygous group of MTHFR gene were significantly higher than those in CT heterozygote group, CC homozygote group and CC homozygote group. There was also significant difference in plasma Hcy concentration between CT heterozygote group and CC homozygote group. There was also significant difference in plasma Hcy level between MTHFR gene TT homozygote group and CC homozygote group. The allele frequencies of MTHFR gene in the is group were significantly higher than those in the control group (57.65) and 38.41% (38.41%), respectively. There was a significant difference between the two groups. Conclusion the increase of plasma Hcy concentration is one of the risk factors of is. There is a negative correlation between plasma Hcy concentration and folic acid and vitamin B12 levels. Vitamin B12 deficiency may be an important reason for the increase of plasma Hcy. The mutation of MTHFR gene may be the main influencing factor of plasma Hcy increase. The mutation of MTHFR gene C677T may be closely related to the susceptibility of is.
【作者单位】：郑州大学第二附属医院干部病房;
【分类号】：R743.3

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