急性轻型缺血性卒中患者的糖化白蛋白水平及临床意义

发布时间：2018-06-18 04:02

本文选题：糖化白蛋白 + 轻型缺血性卒中　；参考：《青岛大学》2017年硕士论文

【摘要】：目的:探讨糖化白蛋白水平与急性轻型缺血性卒中的相关性,进一步分析糖化白蛋白水平在不同病因分型的急性轻型缺血性卒中患者的差异,为不同病因分型急性轻型缺血性卒中的诊治提供理论依据。方法:选择2014年12月至2016年12月在我院神经内科住院的急性轻型缺血性卒中患者145例,对每例患者进行脑血管病危险因素筛查,并检测患者的血清糖化白蛋白指标,再根据患者颅脑MRI、MRA或CTA检查进行CISS卒中病因分型,选出大动脉粥样硬化型(LAA)轻型卒中患者84例和穿支动脉疾病型(PAD)轻型卒中患者61例,选择同期在我院健康体检中心查体的无卒中人群130例作为正常对照,比较急性轻型缺血性卒中组和无卒中对照组的血管危险因素、空腹血糖和糖化白蛋白水平;再进一步比较分析年龄、性别、高血压、糖尿病、高脂血症、空腹血糖和糖化白蛋白水平在LAA组和PAD组的差异是否有统计学意义。结果:与无卒中对照组比较,病例组中高血压、糖尿病、高脂血症、吸烟史、空腹血糖和糖化白蛋白水平明显高于对照组,差异有统计学意义(均P0.05)。亚组分析发现,糖尿病亚组中,轻型卒中组患者糖化白蛋白水平显著高于无卒中对照组[(21.3±4.7)%(17.2±1.9)%,P0.01];在非糖尿病亚组中也得出相似结论。多因素Logistic回归分析显示,在校正常见危险因素后,无论在总人群、糖尿病亚组还是非糖尿病亚组中,糖化白蛋白水平增高均为急性轻型缺血性卒中患者的独立危险因素(P0.05)。LAA组和PAD组两组比较发现,年龄、性别、高脂血症常见危险因素的差异有统计学意义(P0.05),而空腹血糖、糖化白蛋白水平在两组种的差异无统计学意义(P0.05)。结论:本研究提示糖化白蛋白与急性轻型缺血性卒中的发生显著相关,糖化白蛋白水平增高是急性轻型缺血性卒中的独立危险因素;糖化白蛋白水平在LAA组和PAD组的差异无显著统计学意义。
[Abstract]:Objective: To explore the correlation between glycated albumin level and acute light ischemic stroke, and to further analyze the differences of glycated albumin levels in acute light ischemic stroke patients with different etiological types, and to provide a theoretical basis for the diagnosis and treatment of acute light ischemic stroke with different etiological types. Methods: from December 2014 to December 2016. 145 patients with acute light ischemic stroke in the Department of Neurology in our hospital were screened for the risk factors of cerebrovascular disease in each case, and the serum glycosylated albumin index was detected, and then the CISS apoplexy etiological classification was carried out according to the MRI, MRA or CTA examination of the patients, and 84 cases of large atherosclerotic type (LAA) light stroke patients were selected. 61 cases of arterial disease type (PAD) with light stroke were selected as normal controls in 130 cases without stroke in the physical examination center of our hospital. The vascular risk factors of acute light ischemic stroke group and non stroke control group, fasting blood glucose and glycated albumin level were compared, and the age, sex and hypertension were further compared. Whether diabetes, hyperlipidemia, fasting blood glucose and glycated albumin levels were statistically significant in group LAA and group PAD. Results: compared with the non stroke control group, hypertension, diabetes, hyperlipidemia, smoking history, fasting blood glucose and glycated albumin levels were significantly higher in the case group than in the control group (all P0.05). In the group analysis, the glycosylated albumin level in the light stroke group was significantly higher than that in the non stroke control group [(21.3 + 4.7)% (17.2 + 1.9)%, P0.01], and a similar conclusion in the non diabetic subgroup. Multiple factor Logistic regression analysis showed that in the general population, the diabetes subgroup or the non sugar after the normal risk factors were seen in the school. In the urine subgroup, the increased glycated albumin level was the independent risk factor of acute light ischemic stroke (P0.05) group.LAA and group PAD. The difference of common risk factors of age, sex and hyperlipidemia was statistically significant (P0.05), but there was no statistical difference between the fasting blood sugar and the glycosylated albumin level in the two groups. P0.05. Conclusion: This study suggests that glycated albumin is significantly associated with acute light ischemic stroke. The increased glycated albumin level is an independent risk factor for acute light ischemic stroke, and there is no significant difference in the level of glycated albumin in the LAA group and the PAD group.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3

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