宫内生长受限对早产儿脑功能发育的影响

发布时间：2018-06-22 00:40

本文选题：胎儿生长受限 + 脑功能　；参考：《临床儿科杂志》2017年07期

【摘要】：目的探讨宫内生长受限(IUGR)对早产儿脑功能发育的影响。方法采用Nicolet One脑功能监护仪对2015年1月至2016年2月住院、胎龄32~36周的110例早产儿,其中小于胎龄儿(SGA)50例、适于胎龄儿(AGA)60例,于生后72小时内进行监测,每次连续监测4~6小时,比较两组早产儿脑电波形的连续性、睡眠-觉醒周期、爆发间期、最低和最高电压等指标的差异。结果 SGA组振幅整合脑电图(a EEG)连续性脑电图及睡眠-觉醒周期的出现率及最高、最低电压值均低于AGA组,爆发间期则长于AGA组,差异均有统计学意义(P0.05)。在SGA组中,出生体质量P_3组、P_3~P_5组、P_5~P_(10)组之间aEEG的连续性脑电图及睡眠-觉醒周期的出现率、爆发间期、最低和最高电压差异均无统计学意义(P0.05)。结论 SGA早产儿连续性脑电图及睡眠-觉醒周期性出现率减少,爆发间期相对延长,最高及最低电压降低,提示IUGR一定程度上延迟或抑制了早产儿脑功能的发育。
[Abstract]:Objective to investigate the effect of intrauterine growth restriction (IUGR) on brain function in premature infants. Methods from January 2015 to February 2016, 110 premature infants with 32 to 36 weeks of gestational age, including 50 infants with less than gestational age (SGA) and 60 infants of suitable gestational age (AGA), were monitored within 72 hours after birth for 4 consecutive hours. The differences of brain wave shape, sleep-wake-up period, interburst period, lowest voltage and maximum voltage were compared between the two groups. Results the frequency and the lowest voltage of continuous EEG and sleep-wake-up cycle in SGA group were lower than those in AGA group, and the interburst period was longer than that in AGA group (P0.05). In the SGA group, there was no significant difference in the continuous EEG, the occurrence rate of sleep-wakefulness cycle, the interburst period, the lowest voltage and the highest voltage between the three groups (P < 0.05). Conclusion the occurrence rate of continuous electroencephalogram (EEG) and sleep-wake-up periodicity of SGA preterm infants is reduced, the interval between bursts is relatively prolonged, and the highest and lowest voltages are decreased, which suggests that IUGR can delay or inhibit the development of brain function in premature infants to some extent.
【作者单位】：南方医科大学陆军总医院临床医学院附属八一儿童医院;北京市朝阳区妇幼保健院新生儿科;
【基金】：国家自然科学基金资助项目(No.81471087)
【分类号】：R742

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