瑞舒伐他汀联合银杏叶片对脑梗死患者颈动脉粥样硬化斑块及血脂异常的疗效观察

发布时间：2018-06-29 04:35

  本文选题：脑梗死 + 动脉粥样硬化斑块　； 参考：《新乡医学院》2014年硕士论文

【摘要】：目的通过系统全面的临床试验观察,研究瑞舒伐他汀联合银沓叶片对脑梗死患者颈动脉粥样硬化斑块及血脂异常的影响。方法选取新乡医学院第三附属医院神经内科2013.09-2014.01符合纳入标准的患者56例,运用随机数字表的方法将56例病人分为两组,其中治疗组28例：睡前顿服瑞舒伐他汀10mg,合用银杏叶片,每同3次,每次1片；对照组28例：睡前顿服瑞舒伐他汀10mg。本研究观察时限6个月。运用颈动脉多普勒超声分别于治疗前后检测颈动脉内膜-中膜厚度(IMT)及颈动脉粥样硬化斑块,计算斑块面积和斑块总积分；运用全自动生化分析仪检测甘油三酯(TC)、总胆固醇(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。治疗期间需对药物的不良反应进行观察。结果治疗前,对照组及治疗组颈动咏IMT、斑块面积、斑块总积分、TC、TG、LDL-C、 HDL-C比较(P0.05),差异无统计学意义。6个月疗程结束后,与治疗前相比,对照组及治疗组颈动脉IMT、斑块面积、斑块总积分及TC、TG、LDL-C均降低(P0.05),HDL-C升高(P0.05),差异有统计学意义；与对照组比,治疗组斑块IMT、斑块面积水平、斑块总积分及TC、TG、LDL-C降低,HDL-C升高(P0.05),差异有统计学意义。结论 1、瑞舒伐他汀可有效地逆转颈动脉粥样硬化斑块的形成,可以缩小斑块IMT值、斑块总积分及斑块面积,降低血脂。2、瑞舒伐他汀联合银含叶片能更好地逆转脑梗死患者颈动脉粥样硬化斑块的形成,可以缩小斑块IMT值、斑块总积分及斑块面积,且较单用瑞舒伐他汀组疗效更明显。 3、瑞舒伐他汀联合银杏叶对脑梗死患者的血脂水平有明显改善,即降低TC、TG、LDL-C,升高HDL-C,且较单用瑞舒伐他汀组疗效更明显。
[Abstract]:Objective to study the effects of rosuvastatin combined with silverleaf on carotid atherosclerotic plaque and dyslipidemia in patients with cerebral infarction. Methods Fifty-six patients in Department of Neurology, the third affiliated Hospital of Xinxiang Medical College, were selected and divided into two groups by random digital table method: the treatment group (n = 28) received resuvastatin 10mg before bedtime, combined with ginkgo biloba leaf. The control group (n = 28) was treated with rosuvastatin 10 mg before bedtime. The time limit of observation was 6 months. Carotid artery intima-media thickness (IMT) and carotid atherosclerotic plaque were measured by carotid Doppler ultrasound before and after treatment. Plaque area and total plaque score were calculated. The levels of triglyceride (TC), total cholesterol (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured by automatic biochemical analyzer. Adverse drug reactions should be observed during treatment. Results before treatment, there was no significant difference in IMT, plaque area, total plaque score, TGG LDL-C and HDL-C between the control group and the treatment group before treatment (P0.05). After 6 months of treatment, the carotid artery IMT and plaque area in the control group and the treatment group were compared with those before treatment. Compared with the control group, the plaque IMT, plaque area level, plaque total score and TCTGG LDL-C decreased in the treatment group (P0.05), the difference was statistically significant. Conclusion 1. Rosuvastatin can effectively reverse the formation of carotid atherosclerotic plaque, reduce the plaque IMT, total plaque score and plaque area. Reducing blood lipids. 2. The combination of rusuvastatin and silver leaves could reverse the formation of carotid atherosclerotic plaques in patients with cerebral infarction, reduce the IMT value of plaque, the total score of plaque and the area of plaque, and the curative effect was more obvious than that in the group treated with rosuvastatin alone. 3. The serum lipids of patients with cerebral infarction were significantly improved by Risuvastatin combined with ginkgo biloba, that is to say, the level of serum lipids decreased and HDL-C was increased in TCU TGG LDL-C group, and the curative effect was more obvious than that in Risuvastatin alone group.
【学位授予单位】：新乡医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3
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本文编号：2080871