帕金森病临床特征与血脂、血尿酸水平的相关性研究

发布时间：2018-06-29 04:03

本文选题：帕金森病 + 临床特征　；参考：《重庆医科大学》2014年硕士论文

【摘要】：目的：探讨帕金森病（PD）患者临床特征，如病情严重程度病程发病年龄临床类型及每日左旋多巴等效剂量等，与血脂和血尿酸水平的相关性，观察其与帕金森病患者的发病风险以及病情进展的预测之间的关系，为临床指导帕金森病患者的饮食和生活方式提供实验依据方法：回顾性统计分析我院130名帕金森病住院患者的临床资料，分析H-Y分级与起病年龄性别病程的关系；同时比较帕金森病患者与135名非帕金森病人群的血脂（TC TG LDL HDL ApoA1ApoA1/HDL）以及血尿酸水平的差异性；并分析帕金森病患者多巴胺能药物替代治疗（DRT）的每日左旋多巴等效剂量（LEDD）对血脂血尿酸的影响；此外还比较帕金森病的不同临床类型（震颤为主型强直-迟缓为主型混合型）之间血脂和血尿酸有无差异性，以及帕金森病患者H-Y分级病程和发病年龄与血脂血尿酸的相关性结果：130例帕金森病患者平均年龄65.93±10.40岁，男女比例为1.13:1平均起病年龄61.43±10.83岁，平均病程4.5±4.1年，，平均H-Y分级2.28级，平均LEDD为37.5mg其中震颤型28例，强直迟缓型44例，混合型58例，帕金森病患者H-Y分级与年龄病程及LEDD呈正相关，与病程相关性最明显PD组与对照组相比，血尿酸TC TG LDL及ApoA1/HDL差异具有统计学意义PD震颤型与混合型的LDL水平有统计学差异（P＜0.05）， PD强直-迟缓型与震颤型ApoA1/HDL有统计学差异（P＜0.05）帕金森病患者ApoA1/HDL值与H-Y分级呈负相关（P＜0.05），而与病程及发病年龄无相关性帕金森病患者多巴胺能药物治疗剂量与血脂血尿酸无相关性（P＞0.05）结论： 1PD患者病情严重程度与患者年龄病程以及每日左旋多巴剂量呈正相关，与病程相关性最明显，说明随着患者患病时间的延长，病情越来越重，符合帕金森病慢性进行性变性加重的特点 2PD患者TC TG LDL ApoA1/HDL及血尿酸水平均较非帕金森病人群低，说明低血脂和血尿酸水平可能是帕金森病发病的风险因素； 3帕金森病不同临床类型间LDL及ApoA1/HDL比值存在差异； 4帕金森病H-Y分级与ApoA1/HDL呈负相关，表明ApoA1/HDL比值越低，则PD患者病情越重； 5每日左旋多巴等效剂量与血脂血尿酸无相关性，说明多巴胺能药物替代治疗不影响PD患者血脂血尿酸水平
[Abstract]:Objective: to investigate the clinical characteristics of Parkinson's disease (PD), such as the severity of the disease, the age of onset and the daily levodopa equivalent dose, and the correlation with blood lipid and uric acid level. To observe its relationship with the risk of Parkinson's disease and the prediction of disease progression. Methods: the clinical data of 130 patients with Parkinson's disease were analyzed retrospectively and the relationship between H-Y grading and onset age and course of disease was analyzed. Blood lipid (TC TG LDL LDL ApoA 1 / HDL) and serum uric acid levels were compared between patients with Parkinson's disease and 135 patients without Parkinson's disease. The effects of daily levodopa equivalent dose (LEDD) of dopaminergic replacement therapy (DRT) on serum lipids and uric acid were analyzed in patients with Parkinson's disease. In addition, the differences of blood lipids and uric acid among different clinical types of Parkinson's disease (tremor dominated ankylosing and slow mixed type) were also compared. Results the average age of 130 patients with Parkinson's disease was 65.93 卤10.40 years old, the average onset age was 1.13: 1 卤10.83 years, the mean course of disease was 4.5 卤4.1 years. The mean H-Y grade was 2.28, the mean LEDD was 37.5mg, including 28 cases of tremor type, 44 cases of ankylosis retardation type, 58 cases of mixed type. The H-Y grade of Parkinson's disease patients was positively correlated with age course and LEDD, and the most obvious correlation between PD group and control group. Serum uric acid TC TG LDL and ApoA 1 / HDL there were significant differences in LDL levels between PD tremor type and mixed type (P < 0.05), and there was statistical difference between PD ankyle-tardy type and tremor type ApoA 1 / HDL (P < 0.05) in Parkinson's disease patients with ApoA _ 1 / HDL and H-Y score. There was no correlation between the dosage of dopaminergic drugs and serum lipids and uric acid (P > 0.05) in patients with Parkinson's disease (P > 0.05). Conclusion: 1the severity of PD patients is not related to the severity of the disease. The degree was positively correlated with age course and daily levodopa dose. The most significant correlation with the course of disease shows that with the prolongation of the patient's illness time, the disease becomes more and more serious. 2in PD patients, TC TG LDL ApoA 1 / HDL and serum uric acid levels were lower than those in non-Parkinson 's disease group, indicating that hypolipidemia and serum uric acid level may be risk factors of Parkinson's disease. (3) there were differences in LDL and ApoA1 / HDL ratio among different clinical types of Parkinson's disease, and (4) H-Y grade of Parkinson's disease was negatively correlated with ApoA1 / HDL, indicating that the lower the ratio of ApoA1 / HDL, the more serious the disease in PD patients. 5 there was no correlation between daily levodopa equivalent dose and serum lipids and uric acid, indicating that dopaminergic drug replacement therapy had no effect on serum lipids and uric acid levels in PD patients.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.5

【共引文献】