青年脑梗死的危险因素分析

发布时间：2018-06-30 16:40

本文选题：脑梗死 + 危险因素　；参考：《新乡医学院》2017年硕士论文

【摘要】：背景随着社会快节奏的发展,日常不良的生活方式也更多地走进了人们的生活,也因此造成了一些躯体疾患危害着人类的健康,如脑血管病,这种传统意识中的老年病在危害老年人群身体健康的同时也渐渐地地走入了青年人群的生活。青年人群在社会中占据着重要的地位,是社会发展的中间力量,只有加强对青年脑血管病的认识及重视,了解其危险因素所在,才能及早的从根源上预防和治疗青年脑梗死,促动社会的进步。目的探究青年脑梗死的危险因素,为青年缺血性脑血管病的预防以及治疗提供有力的理论基础。方法采用病例对照研究。选取2015年1月-2016年1月于我院神经内科住院确诊为青年脑梗死的患者122例作为实验组,同期门诊体检的118例健康青年为对照组。收集研究对象的一般资料、入院血液学指标,分别选用单因素、多因素logistic回归分析、敏感性分析的方法以探讨青年脑梗死的危险因素特征。结果1、单因素分析显示:青年梗死组与健康青年组之间吸烟、高血压病、糖尿病、高胆固醇、高同型半胱氨酸、高尿酸、高胱抑素C、高碱性磷酸酶、高白细胞计数、高中性粒细胞百分比、高红细胞分布宽度之间的差异有统计学意义(P0.05)。2、多因素回归分析显示:青年梗死组与健康青年组之间高血压病(OR=6.819,95%C I:3.339-13.928)、高尿酸(OR=2.888,95%CI:1.211-6.888)、高胱抑素C(OR=4.978,95%CI:1.405-17.630)、高碱性磷酸酶(OR=4.343,95%CI:1.897-9.941)、高中性粒细胞百分比(OR=9.204,95%CI:1.771-47.823)、高红细胞分布宽度(O R=11.816,95%CI:2.227-62.700)的差异有统计学意义(P0.05)。3、敏感性分析显示:各因素ROC曲线下面积的排序为:高血压高碱性磷酸酶高中性粒细胞百分比高胱抑素C高尿酸高红细胞分布宽度。结论1、吸烟、高血压病、糖尿病、高胆固醇、高同型半胱氨酸、高尿酸、高胱抑素C、高碱性磷酸酶、高白细胞计数、高中性粒细胞百分比、高红细胞分布宽度均是青年脑梗死的危险因素。2、高血压病、高尿酸、高胱抑素C、高碱性磷酸酶、高中性粒细胞百分比、高红细胞分布宽度为青年脑梗死的独立性危险因素。3、各独立性危险因素可以对疾病的发生作简单的预测,且预测价值排序为:高血压高碱性磷酸酶高中性粒细胞百分比高胱抑素C高尿酸高红细胞分布宽度。
[Abstract]:Background with the rapid development of the society, the bad daily life style has come into people's life more often, thus causing some body diseases to endanger the human health, such as cerebrovascular disease. This kind of old age disease of traditional consciousness not only endangers the health of the old people, but also gradually steps into the life of the young people. Young people occupy an important position in the society and are the intermediate force of social development. Only by strengthening the understanding and attention of young cerebrovascular disease and understanding its risk factors, can we prevent and treat young cerebral infarction from the root causes as soon as possible. Stimulate the progress of society. Objective to explore the risk factors of cerebral infarction in young people and to provide a theoretical basis for the prevention and treatment of ischemic cerebrovascular disease in young people. Methods A case-control study was conducted. From January 2015 to January 2016, 122 young patients with cerebral infarction were selected as experimental group and 118 healthy young people in outpatient examination as control group. The general data of the subjects were collected, and the admission hematologic indexes were collected. The single factor, multivariate logistic regression analysis and sensitivity analysis were used to study the risk factors of cerebral infarction in young people. Results 1. Univariate analysis showed that smoking, hypertension, diabetes, high cholesterol, high homocysteine, high uric acid, high cystatin C, high alkaline phosphatase, high white blood cell count, high alkaline phosphatase, high white blood cell count, hypertension, diabetes mellitus, hypercholesterolemia, hyperhomocysteine, high alkaline phosphatase, and high leukocyte count were found between the young infarction group and the Percentage of high neutrophils, There were significant differences in the distribution width of high red blood cells (P0.05). The multivariate regression analysis showed that hypertension was found between the young infarction group and the healthy youth group (ORO 6.819 ~ 95CI: 3.339-13.928), high uric acid (OR2.8888-95CIW 1.211-6.888), high cystatin C (OR4.97895 CIW 1.405-17.630), high alkaline phosphatase (OR4.34395 CIW 1.897-9.941), high neutrophil granulocyte size (1.897-9.941), high neutrophilic acid (OR 2.888C95 CI: 1.405-17.630), high alkaline phosphatase (OR4.343C95), high neutrophil fine granulocyte. The percentage of cells (OR9.20495 CI: 1.771-47.823) and the width of high erythrocyte distribution (O RV 11.816 ~ 95CI: 2.227-62.700) were significantly different (P0.05). Sensitivity analysis showed that the order of the area under the ROC curve was: high blood pressure, high alkaline phosphatase, high neutrophil percentage, high cystatin C High uric acid, high erythrocyte distribution width. Conclusion 1 smoking, hypertension, diabetes, high cholesterol, high homocysteine, high uric acid, high cystatin C, high alkaline phosphatase, high white blood cell count, high neutrophil percentage; Hypererythrocyte distribution width was the risk factor of cerebral infarction in young adults. Hypertension, hyperuric acid, cystatin C, high alkaline phosphatase, high neutrophil percentage. The distribution width of high erythrocyte is the independent risk factor of young cerebral infarction. The independent risk factors can be used to predict the occurrence of the disease. The order of predictive value was as follows: the percentage of high neutrophils in hypertension and alkaline phosphatase was high cystatin C high uric acid high erythrocyte distribution width.
【学位授予单位】：新乡医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.33

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