血管支架对颅内动脉瘤血液动力学的数值模拟

发布时间：2018-07-10 10:07

本文选题：血管支架 + 颅内动脉瘤　；参考：《生物医学工程研究》2016年04期

【摘要】：血管支架作为治疗颅内动脉瘤的新方法被广泛运用到临床中,而且越来越普遍。但由于某些支架植入后不能满足力学要求或对瘤内血液动力学无明显影响,反而更易形成血栓,造成动脉瘤破裂。本研究首先通过结构静力学分析比较矩形截面网格状支架和网丝编织成的圆形截面螺旋形支架的弯曲变形能力及扭转变形能力;然后将网格支架植入实际脑动脉瘤模型,进行流-固耦合模拟仿真,分析血流速度、壁面压力及壁面剪切力变化。结果表明:两种支架能够在不损失径向支撑力的情况下,提供良好的轴向顺应性,且网格状支架的变形能力高于螺旋状支架;支架植入后血液动力学各项指标明显降低。血管支架对颅内动脉瘤血液动力学有很大影响,可为临床治疗动脉瘤提供理论依据。
[Abstract]:As a new method for the treatment of intracranial aneurysms, stent is widely used in clinical practice, and is becoming more and more common. However, because some stents can not meet the mechanical requirements or have no obvious effect on hemodynamics, it is more likely to form thrombus and cause aneurysm rupture. In this study, the bending and torsional deformability of circular spiral scaffolds with rectangular cross-section and reticulated wire were compared by structural statics analysis, and then the grid scaffolds were implanted into the actual cerebral aneurysm model. The flow-solid coupling simulation was carried out to analyze the changes of blood flow velocity, wall pressure and wall shear force. The results show that the two scaffolds can provide good axial compliance without loss of radial support force, and the deformability of grid scaffolds is higher than that of spiral scaffolds, and the hemodynamic parameters are obviously decreased after stent implantation. Stent has great influence on hemodynamics of intracranial aneurysms, which can provide theoretical basis for clinical treatment of aneurysms.
【作者单位】：新疆大学机械工程学院;
【基金】：国家自然科学基金资助项目(51365052)
【分类号】：R743

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