脑小血管病患者中血清尿酸水平与临床症状及脑白质高信号的相关性

发布时间：2018-07-11 18:52

本文选题：脑小血管病 + 血清尿酸　；参考：《广东医学》2017年21期

【摘要】：目的探讨脑小血管病患者血清尿酸水平与临床症状及脑白质高信号病变之间的关系。方法分析行脑部MRI检查的脑小血管病患者共217例,根据患者血清尿酸水平分为高尿酸组和正常组,比较两组患者的Fezakas评分、认知功能障碍、短暂性脑缺血发作(TIA)、步态障碍和头晕、尿失禁等临床症状,并分析血清尿酸水平和Fezakas评分的相关性。结果高尿酸组患者中存在认知功能障碍、头晕和眩晕、既往卒中和TIA的比例显著高于正常组,差异有统计学意义(P0.05),两组的步态障碍和尿失禁症状病例比例比较差异无统计学意义(P0.05),高尿酸组脑室旁高信号中重度和深部白质高信号中重度的比例显著高于正常组(P0.05),血清尿酸水平与脑室旁、深部白质高信号Fezakas评分存在正相关(r=0.352,P0.01;r=0.238,P0.01)。结论脑小血管病合并高尿酸的患者更容易出现认知功能障碍、头晕和眩晕、卒中和TIA的相关症状,其血清尿酸水平与脑室旁、深部白质高信号病变程度呈显著的正相关。
[Abstract]:Objective to investigate the relationship between serum uric acid level and clinical symptoms and hyperintense lesions of white matter in patients with small cerebral angiopathy. Methods 217 patients with small cerebral vascular disease underwent MRI examination were divided into hyperuric acid group and normal group according to their serum uric acid levels. Fezakas score and cognitive impairment were compared between the two groups. Transient ischemic attack (TIA), gait dysfunction, dizziness, urinary incontinence and other clinical symptoms were analyzed, and the correlation between serum uric acid level and Fezakas score was analyzed. Results there were cognitive impairment, dizziness and vertigo in the hyperuricemia group. The proportion of previous stroke and TIA was significantly higher than that in the normal group. The difference was statistically significant (P0.05). There was no significant difference in gait disorder and urinary incontinence between the two groups (P0.05). Group B (P0.05), serum uric acid level and paraventricular level, The high signal Fezakas score in the deep white matter was positively correlated (r = 0.352P 0.01 P = 0.238 / P 0.01). Conclusion patients with small cerebral vascular disease complicated with hyperuricemia are more likely to develop cognitive dysfunction, dizziness and vertigo, stroke and TIA related symptoms. The serum uric acid level is positively correlated with the degree of hyperintense lesions in the paraventricular and deep white matter.
【作者单位】：广东医科大学附属医院神经内科;
【分类号】：R743

【相似文献】