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复方丹参注射液联合丁苯酞注射液治疗急性缺血性脑卒中的临床研究

发布时间:2018-07-14 16:17
【摘要】:目的观察复方丹参注射液联合丁苯酞注射液治疗急性缺血性脑卒中的临床疗效及安全性。方法将58例急性缺血性脑卒中患者作随机分为试验组29例和对照组29例。对照组在常规治疗的基础上静脉滴注丁苯酞注射液,每次25 mg,每日1次,持续治疗14 d。而试验组在对照组的基础上静脉滴注复方丹参注射液,每次20 m L,每日1次,持续治疗14 d,比较2组患者的临床疗效、治疗前后的神经功能缺损评分、血清炎症因子水平[白细胞介素-6(IL-6)、IL-10、IL-β、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)],以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为93.10%(27/29例)和72.41%(21/29例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的神经功能缺损评分分别为(11.03±3.05),(19.28±3.11)分;IL-6分别为(3.12±1.13),(5.21±1.43)ng·L~(-1);IL-10分别为(10.32±2.56),(8.52±2.15)ng·L~(-1);IL-β分别为(0.21±0.11),(10.42±0.29)ng·L~(-1);TNF-α分别为(8.32±1.35),(10.86±2.13)mg·L~(-1);hs-CRP分别为(2.01±0.65),(3.11±1.09)mg·L~(-1),差异有统计学意义(P0.05)。试验组和对照组发生的药物不良反应主要有肺部感染和脑疝,试验组和对照组的药物不良反应发生率分别为17.24%和51.27%,差异有统计学意义(P0.05)。结论复方丹参注射液联合丁苯酞注射液能显著改善患者的神经功能缺损和血清炎症因子水平,治疗急性缺血性脑卒中的临床疗效显著,且安全性较高。
[Abstract]:Objective to observe the efficacy and safety of compound salvia miltiorrhiza injection combined with butyphthalide injection in the treatment of acute ischemic stroke. Methods 58 patients with acute ischemic stroke were randomly divided into trial group (n = 29) and control group (n = 29). In the control group, butyphthalide injection was injected intravenously on the basis of routine treatment, 25 mg / time, once a day, for 14 days. On the basis of the control group, compound salvia miltiorrhiza injection was injected intravenously once a day for 14 days. The clinical efficacy and neurological deficit score before and after treatment were compared between the two groups. Serum levels of inflammatory cytokines [interleukin-6 (IL-6) IL-10 IL-10 IL- 尾, tumor necrosis factor- 伪 (TNF- 伪), hypersensitive C-reactive protein (hs-CRP)] and adverse drug reactions were observed. Results after treatment, the total effective rates of the experimental group and the control group were 93.10% (27 / 29 cases) and 72.41% (21 / 29 cases), respectively. The difference was statistically significant (P0.05). 娌荤枟鍚,

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