醒脑静联合拉莫三嗪、丙戊酸钠治疗老年脑卒中继发性癫痫患者的疗效观察

发布时间：2018-07-15 19:34

【摘要】：目的:探讨中成药醒脑静联合拉莫三嗪、丙戊酸钠治疗老年脑卒中继发性癫痫患者临床效果。方法:选取本院2014年12月—2015年12月收治的76例老年脑卒中继发性癫痫患者进行研究,按照临床试验随机抽样的方法将患者分为两组,其中对照组38例采用拉莫三嗪联合丙戊酸钠进行治疗,观察组38例在对照组的基础上给予中成药醒脑静辅助治疗,疗程均为4周,观察两组患者治疗后的疗效及安全性。结果:观察组治疗后总有效率和显效率分别为94.74%和60.53%,显著高于对照组的78.95%和42.11%,两组治疗后总有效率和显效率相比,差异均有统计学意义,P0.05;两组患者治疗后其癫痫发作次数均显著低于治疗前,P0.05;观察组治疗后癫痫发作次数及发作时持续时间均优于对照组,差异均有统计学意义,P0.05;两组患者治疗期间主要不良反应为皮疹、感觉异常以及胃肠道反应,其中观察组不良反应发生率为10.53%,与对照组不良反应发生率的7.89%相比,差异无统计学意义,P0.05。结论:中成药醒脑静联合拉莫三嗪、丙戊酸钠治疗老年脑卒中继发性癫痫效果显著,且不增加不良反应,具有临床推广价值。
[Abstract]:Objective: to investigate the clinical effect of traditional Chinese patent medicine Xingnaojing combined with lamotriazine and sodium valproate in the treatment of senile patients with secondary epilepsy after stroke. Methods: 76 elderly patients with secondary epilepsy after stroke were selected from December 2014 to December 2015. The patients were randomly divided into two groups according to the random sampling method of clinical trial. 38 cases in the control group were treated with lamotrigine combined with valproate sodium, 38 cases in the observation group were treated with Xingnaojing on the basis of the control group. The course of treatment was 4 weeks. The efficacy and safety of the two groups were observed. Results: the total effective rate and effective rate of the observation group were 94.74% and 60.53, respectively, which were significantly higher than that of the control group (78.95% and 42.11%). The number of epileptic seizures in the two groups was significantly lower than that before treatment, and the number of seizures and the duration of seizures in the observation group were better than those in the control group. The main adverse reactions during treatment were rash, sensory abnormality and gastrointestinal reaction. The incidence of adverse reactions in the observation group was 10.53, compared with 7.89% in the control group. The difference was not statistically significant (P 0.05). Conclusion: the traditional Chinese patent medicine Xingnaojing combined with lamotriazine and sodium valproate is effective in the treatment of senile stroke secondary epilepsy and does not increase adverse reactions.
【作者单位】：天津中医药大学第一附属医院;
【分类号】：R743.3

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