急性缺血性脑卒中患者BPV与IMT的关系及对预后的影响
发布时间:2018-07-15 19:52
【摘要】:目的:探讨不同影像学分型的急性缺血性卒中血压变异性和颈动脉内膜中层厚度之间的关系及其对预后的影响。方法连续选取皖南医学院附属弋矶山医院神经内科2014年9月至2015年6月住院的治疗的急性缺血性卒中患者136例,登记患者基本情况,根据患者入院后的磁共振弥散加权成像(diffusion weighted imaging,DWI)的结果进行影像学分型,并以颈动脉内膜中层厚度(intima media thickness,IMT)为切点,将患者分为IMT1mm组、1mm≤IMT1.5mm组和IMT≥1.5mm组。同时采用24h动态血压监测仪(ambulatory blood pressure monitoring,ABPM)监测血压,选择24h、白昼及夜间的收缩压标准差(systolic blood pressure standard deviation,SSD)和舒张压标准差(diastolic blood pressure standard deviation,DSD)代表血压变异性(blood pressure variability,BPV),分析IMT与BPV间的关系并研究二者对不同影像学分型的急性CIS患者预后的影响。结果:1.高血压在IMT正常组、增厚组及斑块组出现的频率逐渐升高,差异有统计学意义(P0.05),同IMT正常组相比,IMT增厚组与颈动脉斑块组的年龄和FGB均较高,同IMT正常组比较,增厚组的LDL增高,差异有统计学意义(P0.05)。而性别、糖尿病、冠心病、吸烟、UA、TG、HDL等各组间比较均无统计学差异(P0.05)。与IMT正常组比较,IMT增厚组和颈动脉斑块组的24h SSD、24h DSD、d SSD、d DSD、n DSD的值均较大,差异有统计学意义(P0.05),与IMT增厚组相比,颈动脉斑块组的24h SSD的值较大,差异有统计学意义(P0.05)。2.通过IMT与各时段(24h、白昼、夜间)的平均血压及BPV的相关性分析可以看出,IMT与24h SBP、d SBP、24h SSD、24h DSD、d SSD均呈正相关,其中与24h SBP(r=0.403,P=0.008)、24h SSD(r=0.487,P=0.017)的相关性较强。3.预后不良组与预后良好组比较,年龄、高血压病、糖尿病、24h SSD、24h DSD、d SSD、d DSD、FGB的差异均有统计学意义(P0.05)。余各危险因素均无统计学意义,结果提示,年龄、高血压病、糖尿病、24h SSD、24h DSD、d SSD、d DSD、FGB是急性CIS患者6个月时预后的影响因素。继续进行Logistic回归分析,结果发现只有24h SSD、d DSD与6个月预后有关,其余各因素与预后关系不明显,因此,仅24h SSD、d DSD是急性CIS患者6个月预后不良的独立影响因素。4.与后循环梗死组比较,前循环皮质梗死组、基底节区梗死组的24h SSD增高,与放射冠区梗死组和后循环梗死组相比,基底节区梗死组的d SSD增高,差异有统计学意义(P0.05)。与单发梗死相比,多灶梗死的24h SSD、24h DSD、d SSD、n SSD、IMT均高于单发梗死组,差异有统计学意义(P0.05)。结论:1.急性缺血性卒中患者的平均血压及血压变异性与颈动脉内膜中层厚度增加有关。2.24h收缩压变异性和白昼舒张压变异性是急性缺血性卒中患者预后的独立影响因素。3.不同影像学分型的急性缺血性卒中患者的血压变异性不同。
[Abstract]:Objective: to investigate the relationship between blood pressure variability and carotid intima-media thickness in acute ischemic stroke with different imaging types and its influence on prognosis. Methods 136 patients with acute ischemic stroke who were hospitalized from September 2014 to June 2015 in Department of Neurology, affiliated to Southern Anhui Medical College, were selected to register the basic conditions of the patients. According to the results of diffusion weighted (diffusion weighted imaging (DWI) after admission, the patients were divided into IMT 1 mm 鈮,
本文编号:2125199
[Abstract]:Objective: to investigate the relationship between blood pressure variability and carotid intima-media thickness in acute ischemic stroke with different imaging types and its influence on prognosis. Methods 136 patients with acute ischemic stroke who were hospitalized from September 2014 to June 2015 in Department of Neurology, affiliated to Southern Anhui Medical College, were selected to register the basic conditions of the patients. According to the results of diffusion weighted (diffusion weighted imaging (DWI) after admission, the patients were divided into IMT 1 mm 鈮,
本文编号:2125199
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