急性脑梗死患者血清视黄醇结合蛋白水平与颈动脉粥样硬化斑块的相关性研究

发布时间：2018-07-16 19:23

【摘要】：目的探讨急性脑梗死(ACI)患者颈动脉粥样硬化性斑块与视黄醇结合蛋白(RBP)含量的关系。方法选取96例ACI患者(ACI组)和95例正常对照者(对照组),检测血清RBP水平;同时检测ACI组和对照组患者血清尿酸(UA)和血浆D-二聚体(DD)、纤维蛋白原(FIB)水平。对于ACI患者结合其颈动脉超声检查结果,分为无斑块组(41例)、颈动脉稳定斑块组(28例)和颈动脉不稳定斑块组(27例);比较各组血清RBP水平。结果 ACI组血清RBP水平显著高于正常对照组(P0.05)。在ACI患者中,颈动脉稳定斑块组和不稳定斑块组的血清RBP水平较无斑块组明显升高(均P0.05);颈动脉不稳定斑块组血清RBP水平显著高于稳定斑块组(P0.05)。线性相关分析表明,RBP水平和UA、DD和FIB水平无明显相关性(r=0.192,r=0.088,r=0.096,均P0.05)。Logistic回归分析结果显示,RBP是发生颈动脉粥样斑块的危险因素(OR=2.769,95%CI 0.007-0.722)。结论血清RBP可能是动脉硬化形成的一个重要标志物,并且可能与ACI患者动脉粥样硬化斑块的稳定性密切相关。
[Abstract]:Objective to investigate the relationship between carotid atherosclerotic plaque and retinol binding protein (RBP) in patients with acute cerebral infarction (ACI). Methods Serum RBP levels, serum uric acid (UA), plasma D-dimer (DD) and fibrinogen (FIB) levels were measured in 96 patients with ACI and 95 normal controls. Patients with ACI were divided into 4 groups: no plaque group (41 cases), carotid artery stable plaque group (28 cases) and carotid artery unstable plaque group (27 cases). Results the serum RBP level in ACI group was significantly higher than that in normal control group (P0.05). In ACI patients, the serum RBP level in carotid stable plaque group and unstable plaque group was significantly higher than that in non-plaque group (P0.05), and the serum RBP level in carotid unstable plaque group was significantly higher than that in stable plaque group (P0.05). Linear correlation analysis showed that there was no significant correlation between RBP level and DD and FIB levels (r = 0.192). Logistic regression analysis showed that RBP was a risk factor for carotid atherosclerotic plaques (OR2.769 / 95 CI 0.007-0.722). Conclusion Serum RBP may be an important marker of atherosclerosis and may be closely related to the stability of atherosclerotic plaques in ACI patients.
【作者单位】：南通大学第三附属医院/无锡市第三人民医院神经内科;
【分类号】：R743.33

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