胶质母细胞瘤灌注成像与IDH1突变状态的相关性探究

发布时间：2018-07-17 01:14

【摘要】：目的:胶质母细胞瘤是一种具有高侵袭性的恶性肿瘤,也是成年人中最常见的,发病率最高的原发性恶性脑瘤。通过灌注成像所得的成像生物标志物对于这种患者的预后提供了极其重要的信息。相对于无异柠檬酸脱氢酶1(IDH1)突变的胶质瘤患者来说,IDH1突变的患者会有更好的预后。我们的目的是调查是否可以使用核磁灌注成像来预测胶质母细胞瘤的IDH1突变状态。方法:我们回顾性研究了近2年来30名野生型IDH1的胶质母细胞瘤患者和30名突变型IDH1的胶质母细胞瘤患者。使用DCE-MRI和DSC-MRI数据测量肿瘤的Ktrans值、Ve值、rCBF值、rCBV值。我们采用t检验的方法比较了IDH1野生组和IDH1突变组胶质母细胞瘤的灌注数据Ktrans与Ve值及rCBV与rCBF值肿瘤分型的差异性。应用ROC曲线,我们可以分析并获得Ktrans与Ve值,以及rCBV与rCBF值鉴别野生型和突变型胶质母细胞瘤的最佳阈值,同时可判断其特异性和敏感性。结果:野生型IDH1患者的Ktrans值、Ve值、rCBF值、rCBV值显著高于那些突变型IDH1患者(P0.05)。曲线下的面积Ktrans值、Ve值、rCBF值、rCBV值分别为0.850,0.873,0.739,和0.772。结论:来源于灌注核磁影像的Ktrans值、Ve值、rCBF值、rCBV值计算结果对于的预测IDH1突变状态是有用的。
[Abstract]:Objective: glioblastoma is a highly invasive malignant tumor and the most common primary malignant brain tumor in adults with the highest incidence. Imaging biomarkers obtained by perfusion imaging provide extremely important information for the prognosis of these patients. Patients with IDH 1 mutation had a better prognosis than those with isocitrate dehydrogenase 1 (IDH 1) mutation. Our aim is to investigate whether nuclear magnetic perfusion imaging can be used to predict IDH 1 mutation in glioblastoma. Methods: we retrospectively studied 30 patients with wild-type IDH1 glioblastoma and 30 patients with mutant IDH1 glioblastoma in recent 2 years. Using DCE-MRI and DSC-MRI data, the Ktrans value and the value of rCBF and the value of rCBV of tumor were measured. T test was used to compare the difference between Ktrans and ve values and between rCBV and rCBF values of glioblastoma in IDH1 wild group and IDH1 mutant group. By using the ROC curve, we can analyze and obtain the values of Ktrans and ve, as well as the best threshold value of rCBV and rCBF for differentiating wild-type and mutant glioblastoma, at the same time, we can judge their specificity and sensitivity. Results: the values of Ktrans and ve and rCBF were significantly higher in wild IDH1 patients than those in mutant IDH1 patients (P0.05). Under the curve, the area values of Ktrans and ve and rCBF and rCBV are 0.850, 0.873and 0.739, and 0.772respectively. Conclusion: the calculated results of Ktrans value / re value and rCBF value / rCBV value from perfusion nuclear magnetic imaging are useful for predicting IDH1 mutation state.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R739.41

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