缺血性脑卒中患者血清VILIP-1水平与疾病严重程度及预后的相关性研究

发布时间：2018-07-18 11:05

【摘要】：目的:探讨缺血性脑卒中患者血清VILIP-1水平与疾病严重程度及预后的相关性。方法:收集延边地区缺血性脑卒中患者108例,同期年龄、性别相匹配的对照组共103例,按照NIHSS评分量表对缺血性脑卒中患者在入院时进行神经功能缺损评分,严重程度分为轻、中和重型,按改良Rankin量表将患者预后分为完全无症状组、未见明显残障组、轻度残障组、中度残障组、中重度残障组。酶联免疫吸附法(ELISA)检测两组受试者入院时血清VILIP-1浓度含量。结果:(1)不同性别、年龄段卒中组及对照组组间比较血清VILIP-1水平无显著性差异,缺血性脑卒中组VILIP-1水平明显高于对照组(4.23±2.56ng/ml vs.3.03±1.90ng/ml,P0.001);缺血性脑卒中两性患者中血清VILIP-1水平含量均高于对照组。(2)NIHSS评分为轻、中、重型三组的血清VILIP-1水平分别为(3.42±1.63、6.31±1.80、11.17±1.14ng/ml,P0.001),其中之间任意两组的水平均数都具有统计学意义,且随着NIHSS评分的逐渐增高,缺血性脑卒中组血清VILIP-1水平浓度也随之增高;(3)短期预后的结果显示Rankin量表评分的各组间的血清VILIP-1水平之间具有统计学差异(P0.05),中重度残障组血清VILIP-1水平明显高于完全无症状组、未见明显残障组、轻度残障组、中度残障组(P0.05)。随着IS患者预后评分越高,患者血清VILIP-1水平也逐渐增加。(4)多因素Logistic回归分析表明调整了 HCY、CRP、血糖等相关影响预后的因素后,VILIP-1水平仍是影响缺血性脑卒中预后的独立危险因素。结论:(1)血清VILIP-1可作为诊断缺血性脑卒中的参考指标,并可预测缺血性脑卒中的严重程度。(2)血清VILIP-1是影响缺血性脑卒中患者预后的独立危险因素,可预测缺血性脑卒中患者的短期预后。
[Abstract]:Objective: to investigate the correlation between serum VILIP-1 level and severity and prognosis of ischemic stroke patients. Methods: 108 patients with ischemic stroke in Yanbian area and 103 controls with matched age and sex were collected. According to NIHSS score scale, neurological deficit scores were scored on admission. According to the modified Rankin scale, the patients were divided into asymptomatic group, no significant disability group, mild disability group, moderate and severe disability group. Serum levels of VILIP-1 were measured by enzyme linked immunosorbent assay (Elisa). Results: (1) there was no significant difference in serum VILIP-1 levels between stroke group and control group in different sex, age group and control group. The level of VILIP-1 in ischemic stroke group was significantly higher than that in control group (4.23 卤2.56ng/ml vs.3.03 卤1.90 ng / ml P0.001), and the level of VILIP-1 in both sexes of ischemic stroke was higher than that in control group. (2) NIHSS score was mild and moderate. The serum levels of VILIP-1 in the three severe groups were (3.42 卤1.63V 6.31 卤1.80 卤11.17 卤1.14ng / ml P0.001) respectively. The mean water levels in any two groups were statistically significant, and with the increasing of NIHSS score, The level of VILIP-1 in patients with ischemic stroke was also increased. (3) the results of short-term prognosis showed that the levels of VILIP-1 in patients with moderate and severe disability were significantly higher than those in asymptomatic patients (P0.05), and the results of short-term prognosis showed that the levels of VILIP-1 in the groups with Rankin scale score were significantly higher than those in the asymptomatic group. No obvious disability group, mild disability group, moderate disability group (P0.05). The higher the prognosis score of is patients, the higher the level of serum VILIP-1. (4) the multivariate logistic regression analysis showed that adjusted HCYT CRP, blood glucose and other related prognostic factors, VILIP-1 level was still an independent risk factor for the prognosis of ischemic stroke. Conclusion: (1) Serum VILIP-1 can be used as a reference index for the diagnosis of ischemic stroke and can predict the severity of ischemic stroke. (2) Serum VILIP-1 is an independent risk factor for the prognosis of patients with ischemic stroke. It can predict the short-term prognosis of ischemic stroke patients.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3

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