丙戊酸钠对癫痫模型大鼠的认知,行为学和脑电图的影响

发布时间：2018-07-20 20:33

【摘要】：为研究丙戊酸钠对癫痫模型大鼠认知、行为学和脑电图的影响,本次研究选取了60只健康大鼠,随机分为3组(对照组,癫痫组,丙戊酸钠组),每组20只。癫痫组与丙戊酸钠组大鼠通过氯化锂-毛果芸香碱诱导成为癫痫大鼠。造模完成后,给予3组大鼠灌胃给药,对照组与癫痫组使用生理盐水,丙戊酸钠组使用丙戊酸钠,6小时1次,持续5 d。5 d后发现癫痫组与丙戊酸钠组大鼠认知功能显著下降,脑电图频率减慢以及波幅显著增高;与癫痫组相比,丙戊酸钠组癫痫发作次数明显减少,持续时间明显降低。这提示丙戊酸钠可改善癫痫大鼠的认知功能、行为学及脑电图异常。
[Abstract]:In order to study the effect of sodium valproate on cognition, behavior and EEG of epileptic rats, 60 healthy rats were randomly divided into 3 groups (control group, epileptic group and sodium valproate group) with 20 rats in each group. Rats in epilepsy group and sodium valproate group were induced into epileptic rats by lithium chloride-pilocarpine. After the establishment of the model, the rats in the three groups were given intragastric administration, the control group and the epileptic group were given normal saline, and the sodium valproate group was given valproate sodium for 6 hours. After 5 days, the cognitive function of the rats in the epileptic group and the sodium valproate group was significantly decreased. Compared with the epileptic group, the frequency and duration of epileptic seizures in sodium valproate group were significantly decreased. This suggests that sodium valproate can improve cognitive function, behavior and EEG abnormalities in epileptic rats.
【作者单位】：重庆医科大学附属儿童医院神经内科;
【基金】：国家自然科学基金项目(81370179)资助
【分类号】：R-332;R742.1

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