帕金森病外科治疗研究进展
发布时间：2018-07-26 16:11
【摘要】：帕金森病是以运动障碍为主要表现的神经退行性疾病,药物治疗以缓解运动症状为核心。外科治疗始于立体定向技术的应用,以核团毁损术与脑深部电刺激术为主要术式。帕金森病外科治疗可以部分改善临床症状,但不能延缓疾病进展。目前基于神经营养因子及神经递质替代的基因治疗方法正在研究中,它可能是帕金森病治疗较有前景的治疗方案。该文就帕金森病脑深部电刺激术及基因治疗的研究进展予以综述。
[Abstract]:Parkinson's disease is a neurodegenerative disease characterized by dyskinesia. Drug therapy focuses on relieving motor symptoms. Surgical treatment began with the application of stereotactic technique. The main methods were nucleus lesion and deep brain stimulation. Surgical treatment of Parkinson's disease can partly improve the clinical symptoms, but can not delay the progress of the disease. At present, gene therapy based on neurotrophic factor and neurotransmitter substitution is being studied, which may be a promising treatment for Parkinson's disease. This article reviews the progress of deep brain electrical stimulation and gene therapy in Parkinson's disease.
【作者单位】： 同济大学附属同济医院神经内科;
【基金】：国家自然科学基金项目(81371403)
【分类号】：R742.5
[Abstract]:Parkinson's disease is a neurodegenerative disease characterized by dyskinesia. Drug therapy focuses on relieving motor symptoms. Surgical treatment began with the application of stereotactic technique. The main methods were nucleus lesion and deep brain stimulation. Surgical treatment of Parkinson's disease can partly improve the clinical symptoms, but can not delay the progress of the disease. At present, gene therapy based on neurotrophic factor and neurotransmitter substitution is being studied, which may be a promising treatment for Parkinson's disease. This article reviews the progress of deep brain electrical stimulation and gene therapy in Parkinson's disease.
【作者单位】： 同济大学附属同济医院神经内科;
【基金】：国家自然科学基金项目(81371403)
【分类号】：R742.5
【共引文献】
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