颅咽管瘤的复发与其病理类型及年龄的关系研究
发布时间：2018-07-26 20:34
【摘要】：第一部分颅咽管瘤的复发与肿瘤的病理类型的关系研究 目的：通过对颅咽管瘤病理类型资料与肿瘤复发的数据进行分析,明确颅咽管瘤的复发与肿瘤的病理类型之间有无关系,有助于颅咽管瘤患者术后的预后分析和后续治疗方案的选择。 方法：调查自2000年1月至2012年12月间于武汉协和医院神经外科接受颅咽管瘤手术的患者共230例,从中选取有明确病理分型且未失访的病例共59例,收集其临床资料,随访调查患者的复发情况。其中造釉细胞型颅咽管瘤35例,鳞状乳头型患者24例。年龄分布为2岁～66岁,36例为男性患者,23例为女性患者。利用SPSS19.0统计工具分析调查和随访所得的数据,用卡方检验比较两种病例类型的复发率有无显著差异。使用SPSS软件通过寿命表法和Kaplan-Meier法绘制累积无复发生存曲线和累积复发曲线,P0.05认为具有统计学意义。 结果：对符合标准的59例颅咽管瘤患者进行随访,造釉细胞型35例,其中13例复发(复发率37.1%),鳞状乳头型24例,其中3例复发(复发率12.5%)。对颅咽管瘤的病理类型和复发数进行卡方检验,结果提示不同病理类型的颅咽管瘤在复发率上的差异具有统计学意义(P0.05)。以病理类型为单因素,使用SPSS软件对59例颅咽管瘤患者复发所需时间(以月计算)进行分析,通过寿命量表法和Kaplan-Meier法分别得出累计无复发生存曲线和累积复发曲线,提示造釉细胞型颅咽管瘤的复发率要高于鳞状乳头型颅咽管瘤,二者的累积复发率有显著差异(P0.05) 结论：不同病理类型的颅咽管瘤患者复发率存在较大差异,肿瘤的病理类型是影响咽管瘤患者术后复发的重要因素。 第二部分颅咽管瘤的复发与患者年龄的关系研究 目的：收集接受手术的颅咽管瘤患者的年龄资料,结合随访所得的患者复发数据,分析颅咽管瘤的复发与患者年龄有无关联。 方法：调查自2000年1月至2012年12月间武汉协和医院神经外科收治的接受颅咽管瘤手术的患者共230例,除外因联系方式缺失、原有联系方式失效等原因失访者,最终筛选出符合标准的病例共97例。其中63例男性患者,34例女性患者。将研究对象按0-20岁,21～60岁分为少儿组和成人组。对研究对象进行追踪调查,收集其术后有无复发及复发所需的时间(以月计算)。利用SPSS19.0统计工具分析调查和随访所得的数据,用卡方检验比较各年龄段患者的复发率有无显著差异。使用SPSS软件通过寿命量表法和Kaplan-Meier法分别绘制累计无复发生存曲线和累积复发曲线,P0.05认为具有统计学意义。 结果：对符合标准的97例颅咽管瘤患者进行随访,0-20岁的患者共40例,其中14例复发,20～60岁的患者共57例,其中9例复发。对颅咽管瘤按照年龄段的复发率进行卡方检验(表1-1),结果为不同年龄的颅咽管瘤在复发率上的差异不具有统计学意义(P0.05)。使用SPSS软件分析比较两个年龄段的颅咽管瘤患者的累积无复发生存曲线和累积复发曲线,可见结果无显著差异(P0.05)。 结论：虽然不同年龄的颅咽管瘤患者复发率虽无明显差异,但是少儿的颅咽管瘤复发率相比成人有着更高的趋势,年龄也可能是影响咽管瘤患者术后复发的潜在因素。 第三部分颅咽管瘤的病理类型与患者年龄的关系研究 目的：研究颅咽管瘤的病理类型和患者的年龄有无关系。 方法：自2000年1月至2012年12月间武汉协和医院神经外科收治的接受颅咽管瘤手术的患者共230例,筛选出具有明确病理分型的病例共68例。其中38例男性患者,30例女性患者。将研究对象按0-20岁,21～60岁分为少儿组和成人组,分别调查各组中造釉细胞型和鳞状乳头型颅咽管瘤的病例数。利用SPSS19.0统计工具分析调查和随访所得的数据,用卡方检验比较各年龄段造釉细胞型和鳞状乳头型颅咽管瘤的比例有无显著差异。使用SPSS软件对病理类型和年龄进行单因素方差分析,P0.05认为具有统计学意义。 结果：在符合标准的68例颅咽管瘤患者中,0-20岁的患者共31例,其中27例为造釉细胞型,4例为鳞状乳头型,20～60岁的患者共37例,其中11例为造釉细胞型,26例为鳞状乳头型。对颅咽管瘤的病理类型按照年龄段进行卡方检验,结果为不同年龄的颅咽管瘤的病理类型差异有统计学意义(P0.05)。 结论：少儿和成人颅咽管瘤患者好发的病理类型存在较大差异,造釉细胞型多发于儿童,鳞状乳头型多发于成人。
[Abstract]:Part one the relationship between recurrence of craniopharyngioma and pathological types of tumor
Objective: to analyze the pathological type of craniopharyngioma and the data of tumor recurrence, and to identify the relationship between the recurrence of craniopharyngioma and the pathological type of the tumor. It is helpful for the prognosis analysis and the choice of follow-up treatment plan for the patients with craniopharyngioma after operation.
Methods: a total of 230 patients who underwent craniopharyngioma surgery in Department of Neurosurgery of Wuhan Union Hospital from January 2000 to December 2012 were investigated, and 59 cases with clear pathological and non missing cases were selected, and their clinical data were collected and followed up to investigate the recurrence of the patients. 35 cases of enamel type craniopharyngioma, squamous papilloma There were 24 cases. The age distribution was from 2 to 66 years, 36 were male and 23 was female. The data of investigation and follow-up were analyzed by SPSS19.0 statistical tool. There was no significant difference in the recurrence rate of two case types by chi square test. The cumulative non recurrent survival curve was plotted by SPSS software and Kaplan-Meier method. And the cumulative recurrence curve, P 0.05, was statistically significant.
Results: 59 cases of craniopharyngioma were followed up. There were 35 cases of enamel cell type, of which 13 cases had relapse (recurrence rate 37.1%) and 24 cases of squamous papillary type, of which 3 cases relapsed (recurrence rate 12.5%). The pathological type and recurrence number of craniopharyngioma were checked by chi square test, and the results suggested the difference in the recurrence rate of craniopharyngioma with different pathological types. The difference was statistically significant (P0.05). With the pathological type as a single factor, the time required for the recurrence of 59 cases of craniopharyngioma was analyzed using the SPSS software. The cumulative recurrence free survival curve and cumulative recurrence curve were obtained by the life scale and Kaplan-Meier method, suggesting that the relapse rate of the enamel type craniopharyngioma was higher. In the papillary craniopharyngioma, there was a significant difference in the cumulative recurrence rate between the two groups (P0.05).
Conclusion: the recurrence rate of craniopharyngioma patients with different pathological types is quite different. The pathological type of tumor is an important factor affecting postoperative recurrence of patients with pharyngioma.
The relationship between recurrence of craniopharyngioma and age of second patients
Objective: to collect the age data of craniopharyngioma patients undergoing surgery, and to analyze the recurrence of patients with the recurrence of craniopharyngioma, and to analyze the correlation between the recurrence of craniopharyngioma and the age of the patients.
Methods: a total of 230 patients received craniopharyngioma surgery in Department of Neurosurgery of Wuhan Union Hospital from January 2000 to December 2012 were investigated. In addition, 97 cases were selected, including 63 cases of male and 34 female patients. The subjects were divided into the children's group and the adult group at the age of 0-20 and 21~60. The subjects were tracked and the time required for the recurrence and recurrence after the operation was collected. The SPSS19.0 statistical tools were used to analyze the data of the investigation and follow-up, and there was no significant difference in the recurrence rate of the patients in all ages with the chi square test. The use of SPSS soft. The cumulative recurrence free survival curve and cumulative recurrence curve were plotted by life span scale and Kaplan-Meier respectively, and P0.05 showed statistical significance.
Results: 97 cases of craniopharyngioma were followed up. There were 40 cases of 0-20 year old patients, of which 14 had relapsed and 57 were 20~60 years old, of which 9 had recurrences. The recurrence rate of craniopharyngioma at different ages was not statistically significant. Significance (P0.05). The cumulative recurrence survival curve and cumulative recurrence curve of craniopharyngioma patients in two ages were analyzed using SPSS software, and there was no significant difference between the results (P0.05).
Conclusion: Although there is no significant difference in the recurrence rate of patients with craniopharyngiomas at different ages, the recurrence rate of children's craniopharyngioma is higher than that in adults, and age may also be a potential factor affecting postoperative recurrence of pharyngioma.
The relationship between pathological types of third craniopharyngiomas and age of patients
Objective: To study the relationship between the pathological types of craniopharyngioma and the age of the patients.
Methods: from January 2000 to December 2012, 230 cases of craniopharyngioma underwent surgery in Department of Neurosurgery, Wuhan Union Hospital, and 68 cases with clear pathological types were selected, including 38 male and 30 female patients. The subjects were divided into children group and adult group at the age of 0-20 and 21~60 years old, respectively. The number of cases of middle enamel type and squamous papillary craniopharyngioma were analyzed by SPSS19.0 statistical tools, and there was no significant difference in the proportion of the age segments of the enamel and squamous papillary craniopharyngiomas with the chi square test. A single factor variance analysis was performed on the type and age of the disease by using the SPSS software, P 0.05 think it is statistically significant.
Results: of the 68 cases of craniopharyngioma, 31 cases were 0-20 years old, of which 27 were apioid, 4 were squamous papillary, 20~60 years old in 37 cases, of which 11 were enamel type and 26 was squamous papillary. The pathological type of craniopharyngioma was checked by age group, and the result was different age. The pathological types of craniopharyngioma were statistically different (P0.05).
Conclusion: the pathological types of craniopharyngioma in children and adults are quite different.
【学位授予单位】：华中科技大学
【学位级别】：博士
【学位授予年份】：2014
【分类号】：R739.4
本文编号：2147216
[Abstract]:Part one the relationship between recurrence of craniopharyngioma and pathological types of tumor
Objective: to analyze the pathological type of craniopharyngioma and the data of tumor recurrence, and to identify the relationship between the recurrence of craniopharyngioma and the pathological type of the tumor. It is helpful for the prognosis analysis and the choice of follow-up treatment plan for the patients with craniopharyngioma after operation.
Methods: a total of 230 patients who underwent craniopharyngioma surgery in Department of Neurosurgery of Wuhan Union Hospital from January 2000 to December 2012 were investigated, and 59 cases with clear pathological and non missing cases were selected, and their clinical data were collected and followed up to investigate the recurrence of the patients. 35 cases of enamel type craniopharyngioma, squamous papilloma There were 24 cases. The age distribution was from 2 to 66 years, 36 were male and 23 was female. The data of investigation and follow-up were analyzed by SPSS19.0 statistical tool. There was no significant difference in the recurrence rate of two case types by chi square test. The cumulative non recurrent survival curve was plotted by SPSS software and Kaplan-Meier method. And the cumulative recurrence curve, P 0.05, was statistically significant.
Results: 59 cases of craniopharyngioma were followed up. There were 35 cases of enamel cell type, of which 13 cases had relapse (recurrence rate 37.1%) and 24 cases of squamous papillary type, of which 3 cases relapsed (recurrence rate 12.5%). The pathological type and recurrence number of craniopharyngioma were checked by chi square test, and the results suggested the difference in the recurrence rate of craniopharyngioma with different pathological types. The difference was statistically significant (P0.05). With the pathological type as a single factor, the time required for the recurrence of 59 cases of craniopharyngioma was analyzed using the SPSS software. The cumulative recurrence free survival curve and cumulative recurrence curve were obtained by the life scale and Kaplan-Meier method, suggesting that the relapse rate of the enamel type craniopharyngioma was higher. In the papillary craniopharyngioma, there was a significant difference in the cumulative recurrence rate between the two groups (P0.05).
Conclusion: the recurrence rate of craniopharyngioma patients with different pathological types is quite different. The pathological type of tumor is an important factor affecting postoperative recurrence of patients with pharyngioma.
The relationship between recurrence of craniopharyngioma and age of second patients
Objective: to collect the age data of craniopharyngioma patients undergoing surgery, and to analyze the recurrence of patients with the recurrence of craniopharyngioma, and to analyze the correlation between the recurrence of craniopharyngioma and the age of the patients.
Methods: a total of 230 patients received craniopharyngioma surgery in Department of Neurosurgery of Wuhan Union Hospital from January 2000 to December 2012 were investigated. In addition, 97 cases were selected, including 63 cases of male and 34 female patients. The subjects were divided into the children's group and the adult group at the age of 0-20 and 21~60. The subjects were tracked and the time required for the recurrence and recurrence after the operation was collected. The SPSS19.0 statistical tools were used to analyze the data of the investigation and follow-up, and there was no significant difference in the recurrence rate of the patients in all ages with the chi square test. The use of SPSS soft. The cumulative recurrence free survival curve and cumulative recurrence curve were plotted by life span scale and Kaplan-Meier respectively, and P0.05 showed statistical significance.
Results: 97 cases of craniopharyngioma were followed up. There were 40 cases of 0-20 year old patients, of which 14 had relapsed and 57 were 20~60 years old, of which 9 had recurrences. The recurrence rate of craniopharyngioma at different ages was not statistically significant. Significance (P0.05). The cumulative recurrence survival curve and cumulative recurrence curve of craniopharyngioma patients in two ages were analyzed using SPSS software, and there was no significant difference between the results (P0.05).
Conclusion: Although there is no significant difference in the recurrence rate of patients with craniopharyngiomas at different ages, the recurrence rate of children's craniopharyngioma is higher than that in adults, and age may also be a potential factor affecting postoperative recurrence of pharyngioma.
The relationship between pathological types of third craniopharyngiomas and age of patients
Objective: To study the relationship between the pathological types of craniopharyngioma and the age of the patients.
Methods: from January 2000 to December 2012, 230 cases of craniopharyngioma underwent surgery in Department of Neurosurgery, Wuhan Union Hospital, and 68 cases with clear pathological types were selected, including 38 male and 30 female patients. The subjects were divided into children group and adult group at the age of 0-20 and 21~60 years old, respectively. The number of cases of middle enamel type and squamous papillary craniopharyngioma were analyzed by SPSS19.0 statistical tools, and there was no significant difference in the proportion of the age segments of the enamel and squamous papillary craniopharyngiomas with the chi square test. A single factor variance analysis was performed on the type and age of the disease by using the SPSS software, P 0.05 think it is statistically significant.
Results: of the 68 cases of craniopharyngioma, 31 cases were 0-20 years old, of which 27 were apioid, 4 were squamous papillary, 20~60 years old in 37 cases, of which 11 were enamel type and 26 was squamous papillary. The pathological type of craniopharyngioma was checked by age group, and the result was different age. The pathological types of craniopharyngioma were statistically different (P0.05).
Conclusion: the pathological types of craniopharyngioma in children and adults are quite different.
【学位授予单位】：华中科技大学
【学位级别】：博士
【学位授予年份】：2014
【分类号】：R739.4
【参考文献】
相关期刊论文 前2条
1 潘军,漆松涛,邓永键,丁彦青,彭林,李晓强;颅咽管瘤增殖细胞核抗原表达与肿瘤复发的关系[J];第一军医大学学报;2002年04期
2 李宗平;游潮;谭学书;刘平;黄思庆;徐建国;;颅咽管瘤的临床特征与预后的分析[J];华西医学;2008年03期
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