血清抗幽门螺旋杆菌抗体和抗AQP4抗体在中枢神经系统脱髓鞘病中的相关性研究

发布时间：2018-07-28 14:09

【摘要】：目的:探讨血清抗幽门螺旋杆菌抗体(HP-Ig G)和抗AQP4抗体在多发性硬化(MS)、视神经脊髓炎(NMO)中的相关性。方法:对33例MS患者、7例NMO患者和35例健康体检者采用间接酶联免疫吸附法(ELISA法)检测血清中抗HP的Ig G抗体,采用细胞间接免疫荧光法(CBA)检测血清标本抗AQP4抗体;分析MS、NMO患者中HP-Ig G及抗AQP4抗体的阳性率,并对比抗AQP4抗体阳性与抗AQP4抗体阴性患者间HP-Ig G阳性率的差别。结果:MS组、NMO组和正常对照组血清中抗血清HP-IgG抗体阳性率分别为69.70%、85.71%、42.86%,差别有统计学意义(P0.05),其中MS组、NMO组与正常对照组血清中抗HP-Ig G抗体阳性率差别均有统计学意义(P0.05);但MS组与NMO组血清中抗HP-Ig G抗体阳性率差别无统计学意义(P0.05)。MS组、NMO组和正常对照组血清中抗AQP4抗体阳性率分别为4.2%、85.71%、0%,差别有统计学意义(P0.05)。MS组和NMO患者组中抗AQP4抗体阳性患者与抗AQP4抗体阴性患者抗HP-IgG抗体阳性率分别为72.73%、79.31%,差别无统计学意义(P0.05)。结论:HP感染是引起MS及NMO疾病发生的危险因素,而与MS及NMO患者是否含有抗AQP4抗体无关。
[Abstract]:Objective: To investigate the correlation between serum anti Helicobacter pylori antibody (HP-Ig G) and anti AQP4 antibody in multiple sclerosis (MS) and optic neuromyelitis (NMO). Methods: 33 cases of MS, 7 NMO patients and 35 healthy subjects were detected by indirect enzyme linked immunosorbent assay (ELISA method) to detect Ig G antibody in serum, and indirect immunofluorescence was used. The positive rate of HP-Ig G and anti AQP4 antibody in MS and NMO patients was analyzed by CBA, and the difference of HP-Ig G positive rate between anti AQP4 antibody positive and anti AQP4 negative patients was compared. The results showed that the positive rate of anti serum antibody in the serum of MS group and normal control group was 69.70%, 85.71%, 42.86%, respectively. There were statistical significance (P0.05), in group MS, the positive rate of anti HP-Ig G antibody in serum of NMO group and normal control group was statistically significant (P0.05), but there was no significant difference in the positive rate of anti HP-Ig G antibody between group MS and NMO group (P0.05), and the positive rate of anti G antibody in serum was 4.2%, 85.71%, 0%, respectively. The difference was statistically significant (P0.05) in group.MS and NMO patients, the positive rate of anti HP-IgG antibody in anti AQP4 antibody positive patients and anti AQP4 negative patients was 72.73% and 79.31% respectively, the difference was not statistically significant (P0.05). Conclusion: HP infection was a risk factor for the occurrence of MS and NMO diseases, but not with MS and NMO patients.
【作者单位】：南昌大学研究生院;江西省人民医院神经内科;
【基金】：江西省科技厅科研院所基础设施配套项目(20123BBA13050) 国家临床重点专科建设项目(卫办医政函[2012]649号)
【分类号】：R744.5

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