高敏C反应蛋白及糖化血红蛋白与高血压脑出血患者颈动脉粥样硬化斑块的相关性

发布时间：2018-07-30 06:39

【摘要】：目的探讨高敏C反应蛋白(hs-CRP)及糖化血红蛋白(Hb A1c)与高血压脑出血患者颈动脉粥样硬化斑块的相关性。方法抽取96例高血压脑出血患者作为研究组,根据颈总动脉内膜厚度(IMT)将其分为重度粥样硬化组(n=32)、轻度粥样硬化组(n=33)、单纯脑出血组(n=31),另选取31例同期体检健康者作对照组。对比四组生化指标水平、颈动脉血管病变影响因素及不同类型斑块患者hs-CRP及Hb A1c水平,并分析各指标与IMT的相关性。结果四组空腹血糖水平对比差异无统计学意义(P0.05),hs-CRP、Hb A1c、IMT、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯水平对比差异均有统计学意义(P0.05),其中单纯脑出血组总胆固醇、低密度脂蛋白、高密度脂蛋白、hs-CRP、Hb A1c水平高于对照组(P0.05);重度粥样硬化组及轻度粥样硬化组hs-CRP、Hb A1c、IMT、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯水平均高于对照组(P0.05),且重度粥样硬化组hs-CRP、Hb A1c最高;IMT与hs-CRP、Hb A1c呈正相关;hs-CRP、Hb A1c、IMT均是颈动脉粥样硬化斑块形成的危险因素(P0.05);软斑患者hs-CRP及Hb A1c水平明显高于溃疡斑、扁平斑、硬斑患者(P0.05)。结论 hs-CRP及Hb A1c均是导致高血压脑出血患者发生颈动脉粥样硬化斑块的危险因素。
[Abstract]:Objective to investigate the relationship between Gao Min C-reactive protein (hs-CRP) and glycosylated hemoglobin (HbA1c) and carotid atherosclerotic plaque in patients with hypertensive intracerebral hemorrhage. Methods 96 patients with hypertensive intracerebral hemorrhage were selected as study group and divided into severe atherosclerosis group (n = 32), mild atherosclerosis group (n = 33) and intracerebral hemorrhage group (n = 31) according to carotid intima thickness (IMT). The levels of hs-CRP and HbA1c in patients with different types of plaque were compared, and the correlation between the indexes and IMT was analyzed. Results there was no significant difference in fasting blood glucose levels among the four groups (P0.05). There were significant differences in the levels of hs-CRPnHbA1cCIMT, HDL, LDL-C, TC and TG (P0.05), among which the total cholesterol in the intracerebral hemorrhage group was higher than that in the control group. The levels of HbA1c in low density lipoprotein (LDL) and high density lipoprotein (HDL-C) were higher than those in control group (P0.05), while in severe atherosclerosis group and mild atherosclerotic group, hs-CRPnHbA1cT, high density lipoprotein, low density lipoprotein, total cholesterol, high density lipoprotein, low density lipoprotein, total cholesterol, The levels of triglyceride were significantly higher than those of the control group (P0.05), and the levels of hs-CRP1c HbA1c in severe atherosclerosis were positively correlated with hs-CRP1c HbA1c (P0.05), the levels of hs-CRP and HB A1c in patients with soft plaque were significantly higher than those in ulceral plaque, flat plaque. Patients with hard spot (P0.05). Conclusion hs-CRP and HB A 1c are risk factors for carotid atherosclerotic plaque in patients with hypertensive intracerebral hemorrhage.
【作者单位】：荆州市第二人民医院神经内科;荆州市第二人民医院神经外科;荆州市第二人民医院B超科;
【基金】：湖北省自然科学基金资助项目(2013CFB080)
【分类号】：R743.34

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