75岁以上帕金森病患者脑深部电刺激术疗效分析

发布时间：2018-08-01 13:28

【摘要】：目的探讨75岁以上原发性帕金森病患者行丘脑底核(subthalamic nucleus,STN)脑深部电刺激术(deep brain stimulation,DBS)的临床疗效。方法收集我科行STN-DBS治疗的24例原发性帕金森病患者,分为A、B两组进行对比研究。A组(75岁)16例,B组(≥75岁)8例。对两组患者疗效及并发症进行对比分析(平均随访7.5个月)。结果患者术后帕金森氏病综合评分量表(unified Parkinson's disease rating scale,UPDRS)评分改善比较,其中UPDRSⅢ75岁以上患者与75岁以下患者两组比较无差异(Z=-0.429,P=0.668),UPDRSⅡ及ADL评分改善百分比两组统计也无差异(Z=-0.551,P=0.581)。帕金森病39问卷表(Parkinson’s disease questionnaire-39,PDQ-39)评分改善两组无差异(Z=-0.245,P=0.806)。美多芭剂减少量两组比较无差异(Z=-0.282,P=0.778)。24例患者并发症(术后90 d内):术后嗜睡和谵妄,A组3例,B组2例;精神症状,A组1例,B组2例;术后肺部感染,A组1例,B组1例;右侧锁骨下皮下积液,B组1例;幻觉,B组1例;手术切口延迟愈合,A组1例,B组1例。远期并发症:构音障碍,体重增加发生率无明显差别。结论表明75岁以上帕金森病患者STN-DBS手术同样取得疗效,并发症发生率有所增加。
[Abstract]:Objective to investigate the clinical effect of (deep brain stimulation in patients with primary Parkinson's disease (PD) over 75 years of age. Methods Twenty-four patients with primary Parkinson's disease treated with STN-DBS were divided into two groups: group A (aged 75), group B (n = 16) and group B (鈮，

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