当前位置:主页 > 医学论文 > 神经病学论文 >

弥散张量成像FA值和ADC值在胶质瘤分级和肿瘤浸润中应用的Meta分析

发布时间:2018-08-01 14:26
【摘要】:目的:评价弥散张量成像FA值及ADC值在胶质瘤分级和肿瘤浸润中应用的价值和意义 方法:不受限于盲法及发表状态,以“弥散张量成像”、“部分各向异性”、“表观弥散系数”、“胶质瘤”、“Diffusion Tensor Imaging”、“Glioma”、“apparentdiffusioncoefficient”、“fractional anisotropy”、“ADC”、“FA”为关键词或主题词,经两名系统评价员共同商议后,以“关键词:表观弥散系数or关键词:ADC or关键词:部分各向异性or FA and关键词:胶质瘤”为检索式在中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方数据库、维普数据库中行计算机检索;以“(apparent diffusion coefficient) OR ADC OR (fractional anisotropy) OR FA ANDGlioma[MeSH Terms] AND humans[MeSH Terms]”为检索式在Pubmed数据库、EMBASE数据库中行计算机检索;在神经外科学杂志、神经影像学杂志和神经外科学领域的学术会议论文集中,行手工检索;查阅相关综述性文章的参考文献,行手工检索;通过与著作者联系的方式追踪还未发表的文章。应用NICE推荐的评分标准对纳入的文献进行质量评价。在胶质瘤的分级和胶质瘤的肿瘤浸润两个方面行Meta分析。 结果:最终有15篇关于FA值及ADC值在胶质瘤分级和肿瘤浸润中应用的文献被纳入本研究中。首先对这些文献进行异质性检验,如果存在异质性,采用随机效应模型;如果存在同质性,采用固定效应模型。合并分析结果如下: ⑴LGG肿瘤实质区的FA值低于HGG肿瘤实质区的FA值(WMD合并=-0.02,95%CI[-0.03,-0.01]),结果有统计学意义;LGG肿瘤实质区的ADC值高于HGG肿瘤实质区的ADC值(WMD合并=0.15,95%CI[0.02,0.28]),结果有统计学意义。 ⑵LGG肿瘤实质区的FA值低于瘤周水肿区的FA值(WMD合并=-0.13,95%CI[-0.19,-0.07]),结果有统计学意义;LGG肿瘤实质区的ADC值高于瘤周水肿区的ADC值(WMD合并=0.21,95%CI[0.05,0.37]),结果有统计学意义。LGG瘤周水肿区的FA值低于正常白质区的FA值(WMD合并=-0.08,95%CI[-0.14,-0.03]),结果有统计学意义;LGG瘤周水肿区的ADC值高于正常白质区的ADC值(WMD合并=0.38,95%CI[0.14,0.61]),结果有统计学意义。LGG肿瘤实质区的FA值低于正常白质区的FA值(WMD合并=-0.25,95%CI[-0.29,-0.21]),结果有统计学意义;LGG肿瘤实质区的ADC值高于正常白质区的ADC值(WMD合并=0.57,95%CI[0.24,0.89]),结果有统计学意义。 ⑶HGG肿瘤实质区的FA值低于瘤周水肿区的FA值(WMD合并=-0.07,95%CI[-0.12,-0.02]),结果有统计学意义;HGG肿瘤实质区的ADC值与瘤周水肿区无差异(WMD合并=-0.02,95%CI[-0.12,0.08],结果无统计学意义)。HGG瘤周水肿区的FA值低于正常白质区的FA值(WMD合并=-0.20,95%CI[-0.27,-0.13]),结果有统计学意义;HGG瘤周水肿区的ADC值高于正常白质区的ADC值(WMD合并=0.52,95%CI[0.39,0.66]),结果有统计学意义。HGG肿瘤实质区的FA值低于正常白质区的FA值(WMD合并=-0.27,95%CI[-0.34,-0.19]),结果有统计学意义;HGG肿瘤实质区的ADC值高于正常白质区的ADC值(WMD合并=0.47,95%CI[0.42,0.52]),结果有统计学意义。 结论: ⑴弥散张量成像FA值和ADC值有助于确定胶质瘤的分级。 ⑵弥散张量成像FA值有助于判定LGG和HGG的肿瘤浸润程度,有助于手术方案的制定;ADC值有助于判定LGG的肿瘤浸润情况,对于判定HGG的肿瘤浸润情况无意义。 ⑶由于我们纳入的各项研究间存在异质性,,某些研究质量偏低,以及存在潜在的发表偏倚和语种偏倚,所以还需要进一步的高质量的病例系列研究,从而对FA值及ADC值在胶质瘤分级和肿瘤浸润中的应用进行更为系统、全面、深入的评价。
[Abstract]:Objective: To evaluate the value and significance of diffusion tensor imaging (FA) and ADC in glioma grading and tumor invasion.
Methods: not limited to blind and published state, with "diffuse tensor imaging", "partial anisotropy", "apparent diffusion coefficient", "glioma", "Diffusion Tensor Imaging", "Glioma", "apparentdiffusioncoefficient", "fractional anisotropy", "ADC", "FA" as key words or subject words, through two families. After the common negotiators, "Keywords: apparent diffusion coefficient or keywords: ADC or key words: partial anisotropic or FA and key words: glioma" as the retrieval type in the Chinese biomedical literature database (CBM), Chinese knowledge network (CNKI), Wanfang database, and the vitamin database, with "apparent diffusion coeffi" Cient) OR ADC OR (fractional anisotropy) OR FA ANDGlioma[MeSH Terms] AND humans[MeSH. The references of the sex articles were made by hand; the unpublished articles were traced by the authors' contact with the authors. The quality of the included literature was evaluated with the NICE recommended scoring criteria. The Meta analysis was performed in two aspects of glioma classification and glioma infiltration.
Results: in the final 15 papers on the application of FA and ADC values in glioma classification and tumor infiltration were included in this study. First of all, the heterogeneity of the literature was tested. If there was heterogeneity, a random effect model was used. If there was a homogeneity, a fixed effect model was used. The results of the combined analysis were as follows:
The FA value of the parenchymal area of LGG was lower than the FA value of HGG tumor parenchyma (WMD with =-0.02,95%CI[-0.03, -0.01]), and the results were statistically significant. The ADC value of the parenchymal area of LGG was higher than the ADC value of the HGG tumor parenchyma (WMD merged), and the results were statistically significant.
The FA value of LGG tumor parenchyma was lower than the FA value of the peritumoral edema area (WMD combined with =-0.13,95%CI[-0.19, -0.07]), and the results were statistically significant. The ADC value of the parenchyma region of LGG was higher than the ADC value of the edema area in the peritumoral area (WMD combined =0.21,95%CI[0.05,0.37]). MD combined with =-0.08,95%CI[-0.14, -0.03]), the results were statistically significant. The ADC value in the edema area of LGG was higher than that of the normal white matter region (WMD with =0.38,95%CI[0.14,0.61]). The results showed statistically significant FA values in the parenchymal area of.LGG lower than that of the normal white matter region. The ADC value of LGG tumor parenchyma was higher than that of normal white matter (WMD = 0.57,95% CI [0.24,0.89]), and the results were statistically significant.
(3) the FA value of HGG tumor parenchyma was lower than the FA value of the peritumoral edema area (WMD combined with =-0.07,95%CI[-0.12, -0.02]), and the results were statistically significant. The ADC value of the parenchymal area of HGG was not different from that of the peritumoral edema area (WMD combined =-0.02,95%CI[-0.12,0.08], the results were not statistically significant). D combined with =-0.20,95%CI[-0.27, -0.13]), the results were statistically significant. The ADC value in the edema area of HGG was higher than that of the normal white matter region (WMD with =0.52,95%CI[0.39,0.66]). The results showed statistically significant FA values in the parenchymal area of.HGG lower than that of the normal white matter region. The ADC value of HGG tumor parenchyma was higher than that of normal white matter (WMD combined = 0.47,95% CI [0.42,0.52]), the results were statistically significant.
Conclusion:
Diffusion tensor imaging FA and ADC values are helpful in determining the grading of gliomas.
(2) the FA value of diffusion tensor imaging helps to determine the degree of tumor infiltration in LGG and HGG, which is helpful to the formulation of the operation scheme, and the ADC value helps to determine the invasion of the tumor in LGG, and is meaningless to determine the infiltration of the tumor in the HGG.
(3) because of the heterogeneity, low quality, potential publication bias and language bias, further high quality case studies are needed to make a more systematic, comprehensive and in-depth evaluation of the FA value and ADC value in glioma classification and tumor infiltration.
【学位授予单位】:吉林大学
【学位级别】:硕士
【学位授予年份】:2014
【分类号】:R739.41

【共引文献】

相关期刊论文 前10条

1 金晶;王龙胜;;病案点评[J];安徽医学;2009年12期

2 ;Platelet-derived growth factor receptor alpha in glioma:a bad seed[J];癌症;2011年09期

3 谢云鹏;田甜;申兴斌;王维兴;钱涛;;星形细胞瘤组织TGF-β1、Smad7与VEGF的表达及意义[J];承德医学院学报;2011年01期

4 钱银锋;殷敏敏;余永强;;扩散加权成像在低级别胶质瘤的鉴别诊断价值[J];磁共振成像;2010年01期

5 刘新新;韩晓雨;李智勇;苗延巍;;侧脑室内未成熟畸胎瘤1例MRI分析[J];磁共振成像;2010年06期

6 王斐斐;程敬亮;赵艺蕾;张勇;闫晨宇;白洁;张会霞;崔晓琳;;动态磁敏感对比MR灌注成像对脑膜瘤分级的临床价值[J];磁共振成像;2011年01期

7 宋茜;齐悦彤;李莹;;第三脑室脊索样胶质瘤1例[J];磁共振成像;2011年02期

8 刘才保;康厚艺;周鹏程;肖华亮;张伟国;;椎管内弥漫性黑色素细胞增生症1例[J];磁共振成像;2011年06期

9 赵君;周俊林;张静;;不同分级少突胶质细胞肿瘤的MRI诊断[J];磁共振成像;2012年01期

10 ;Gliomatosis Cerebri[J];Chinese Journal of Clinical Oncology;2008年04期

相关会议论文 前4条

1 姜新义;陈亮岑;王霄;沙先谊;方晓玲;;基于整合素受体介导的长循环碳酸酯纳米粒对恶性脑胶质瘤靶向递药研究[A];2011年中国药学大会暨第11届中国药师周论文集[C];2011年

2 Yuya Yoshida;Mitsutoshi Nakada;Naotoshi Sugimoto;Tomoya Harada;Yasuhiko Hayashi;Daisuke Kita;Naoyuki Uchiyama;Yutaka Hayashi;Akihiro Yachie;Yoh Takuwa;Jun-ichiro Hamada;;Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival[A];中国抗癌协会神经肿瘤专业委员会第八届学术会议论文集[C];2011年

3 ;Histologic research of microcirculation patterns in human and xengraft model glioblastoma[A];中国抗癌协会神经肿瘤专业委员会第八届学术会议论文集[C];2011年

4 Yuya Yoshida;Mitsutoshi Nakada;Tomoya Harada;Shingo Tanaka;Takuya Furuta;Yasuhiko Hayashi;Daisuke Kita;Naoyuki Uchiyama;Yutaka Hayashi;Jun-ichiro Hamada;;The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients[A];中国抗癌协会神经肿瘤专业委员会第八届学术会议论文集[C];2011年

相关博士学位论文 前10条

1 蒋震;神经系统肿瘤及瘤周血管的磁共振成像研究[D];苏州大学;2010年

2 别黎;跨平台整合微阵列数据筛选与胶质瘤级别相关基因的实验研究[D];吉林大学;2011年

3 王春琳;MDM4在人脑胶质母细胞瘤中的表达与功能研究[D];第二军医大学;2011年

4 陶帮宝;Stathmin在胶质细胞瘤表达及其化疗药物敏感性研究[D];第二军医大学;2011年

5 李维卿;Med19在星形细胞瘤中的表达及对其恶性生物学行为调控的实验研究[D];第二军医大学;2011年

6 赵世斗;OCT4假基因在胶质瘤和乳腺癌中的表达及其意义的研究[D];山东大学;2011年

7 彭雍;RIP3对胶质母细胞瘤细胞增殖、死亡和化疗敏感性的作用及其作用机制的研究[D];中南大学;2011年

8 陈若琨;RAS超家族基因RRP22在星形胶质瘤中的表达及对其生物学行为影响[D];中南大学;2011年

9 沈明;负性共刺激分子B7-H1在A2B5阳性人脑胶质瘤干细胞样细胞中的负性调控作用探讨[D];复旦大学;2011年

10 范薇薇;中国汉族人群脑胶质瘤遗传易感性研究[D];复旦大学;2011年

相关硕士学位论文 前10条

1 颜伟;人胶质瘤中骨桥蛋白功能的初步研究[D];南京医科大学;2010年

2 李丹;扩散张量成像对脑恶性胶质瘤和转移瘤的鉴别诊断价值研究[D];郑州大学;2010年

3 苏国军;人脑星形细胞瘤细胞体外化疗药物敏感性实验研究[D];桂林医学院;2010年

4 陈玉升;胶质瘤患者血清OY-TES-1截短蛋白抗体的检测及临床意义分析[D];广西医科大学;2011年

5 陈有林;脑源性神经营养因子与Neuritin基因在胶质瘤中的表达与意义[D];泸州医学院;2011年

6 赵玮;CCNG2在脑胶质瘤中的表达及与化疗关系的实验研究[D];第二军医大学;2011年

7 刘建莉;颅内不同分化血管外皮细胞瘤的影像与P73因子表达的相关性研究[D];兰州大学;2011年

8 张小林;脑胶质瘤中内源性大麻素代谢酶的表达及其与肿瘤病理级别相关性的研究[D];福建医科大学;2011年

9 王佳宁;颅内肿瘤影像与病理对照研究[D];河北医科大学;2011年

10 王书杰;EGF+61 G/A与脑胶质瘤易感性分析[D];复旦大学;2011年



本文编号:2157866

资料下载
论文发表

本文链接:https://www.wllwen.com/yixuelunwen/shenjingyixue/2157866.html


Copyright(c)文论论文网All Rights Reserved | 网站地图 |

版权申明:资料由用户1a59e***提供,本站仅收录摘要或目录,作者需要删除请E-mail邮箱bigeng88@qq.com