弥散张量成像FA值和ADC值在胶质瘤分级和肿瘤浸润中应用的Meta分析
[Abstract]:Objective: To evaluate the value and significance of diffusion tensor imaging (FA) and ADC in glioma grading and tumor invasion.
Methods: not limited to blind and published state, with "diffuse tensor imaging", "partial anisotropy", "apparent diffusion coefficient", "glioma", "Diffusion Tensor Imaging", "Glioma", "apparentdiffusioncoefficient", "fractional anisotropy", "ADC", "FA" as key words or subject words, through two families. After the common negotiators, "Keywords: apparent diffusion coefficient or keywords: ADC or key words: partial anisotropic or FA and key words: glioma" as the retrieval type in the Chinese biomedical literature database (CBM), Chinese knowledge network (CNKI), Wanfang database, and the vitamin database, with "apparent diffusion coeffi" Cient) OR ADC OR (fractional anisotropy) OR FA ANDGlioma[MeSH Terms] AND humans[MeSH. The references of the sex articles were made by hand; the unpublished articles were traced by the authors' contact with the authors. The quality of the included literature was evaluated with the NICE recommended scoring criteria. The Meta analysis was performed in two aspects of glioma classification and glioma infiltration.
Results: in the final 15 papers on the application of FA and ADC values in glioma classification and tumor infiltration were included in this study. First of all, the heterogeneity of the literature was tested. If there was heterogeneity, a random effect model was used. If there was a homogeneity, a fixed effect model was used. The results of the combined analysis were as follows:
The FA value of the parenchymal area of LGG was lower than the FA value of HGG tumor parenchyma (WMD with =-0.02,95%CI[-0.03, -0.01]), and the results were statistically significant. The ADC value of the parenchymal area of LGG was higher than the ADC value of the HGG tumor parenchyma (WMD merged), and the results were statistically significant.
The FA value of LGG tumor parenchyma was lower than the FA value of the peritumoral edema area (WMD combined with =-0.13,95%CI[-0.19, -0.07]), and the results were statistically significant. The ADC value of the parenchyma region of LGG was higher than the ADC value of the edema area in the peritumoral area (WMD combined =0.21,95%CI[0.05,0.37]). MD combined with =-0.08,95%CI[-0.14, -0.03]), the results were statistically significant. The ADC value in the edema area of LGG was higher than that of the normal white matter region (WMD with =0.38,95%CI[0.14,0.61]). The results showed statistically significant FA values in the parenchymal area of.LGG lower than that of the normal white matter region. The ADC value of LGG tumor parenchyma was higher than that of normal white matter (WMD = 0.57,95% CI [0.24,0.89]), and the results were statistically significant.
(3) the FA value of HGG tumor parenchyma was lower than the FA value of the peritumoral edema area (WMD combined with =-0.07,95%CI[-0.12, -0.02]), and the results were statistically significant. The ADC value of the parenchymal area of HGG was not different from that of the peritumoral edema area (WMD combined =-0.02,95%CI[-0.12,0.08], the results were not statistically significant). D combined with =-0.20,95%CI[-0.27, -0.13]), the results were statistically significant. The ADC value in the edema area of HGG was higher than that of the normal white matter region (WMD with =0.52,95%CI[0.39,0.66]). The results showed statistically significant FA values in the parenchymal area of.HGG lower than that of the normal white matter region. The ADC value of HGG tumor parenchyma was higher than that of normal white matter (WMD combined = 0.47,95% CI [0.42,0.52]), the results were statistically significant.
Conclusion:
Diffusion tensor imaging FA and ADC values are helpful in determining the grading of gliomas.
(2) the FA value of diffusion tensor imaging helps to determine the degree of tumor infiltration in LGG and HGG, which is helpful to the formulation of the operation scheme, and the ADC value helps to determine the invasion of the tumor in LGG, and is meaningless to determine the infiltration of the tumor in the HGG.
(3) because of the heterogeneity, low quality, potential publication bias and language bias, further high quality case studies are needed to make a more systematic, comprehensive and in-depth evaluation of the FA value and ADC value in glioma classification and tumor infiltration.
【学位授予单位】:吉林大学
【学位级别】:硕士
【学位授予年份】:2014
【分类号】:R739.41
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