严重脑白质疏松症相关因素的病例对照研究

发布时间：2018-08-13 11:19

【摘要】：目的探讨严重脑白质疏松症的相关因素。方法按照筛选标准连续收集2015年4月-2016年2月武汉大学中南医院神经内科住院患者,通过头部核磁共振评估脑白质疏松症Fazekas评分并收集相关临床资料,并应用非条件Logistic回归来分析严重脑白质疏松症的相关因素。结果共纳入608例患者,包括Fazekas评分为0的对照组415例和Fazekas评分为3~6的病例组193例。多因素Logistic回归结果提示:高龄(G3 vs G1:OR10.81,95%CI 2.76~42.38,P=0.001;G4 vs G1:OR 28.40,95%CI 7.02~114.95,P0.05;G5 vs G1:OR 68.79,95%CI 14.22~332.92,P0.05)、脑动脉粥样硬化(OR 1.98,95%CI 1.07~3.65,P=0.029)和高血压病(OR=4.84,95%CI=2.65~8.85,P0.05)与严重脑白质疏松症之间呈显著正相关。结论高龄、脑动脉粥样硬化和高血压病可能是严重脑白质疏松症的独立危险因素。
[Abstract]:Objective to investigate the related factors of severe leukoaraiosis. Methods according to the screening criteria, the inpatients in the Department of Neurology, Central South Hospital, Wuhan University from April 2015 to February 2016 were collected. The Fazekas score of leukoaraiosis was evaluated by head MRI and the relevant clinical data were collected. Non-conditional Logistic regression was used to analyze the related factors of severe leukoaraiosis. Results A total of 608 patients were included, including 415 patients with Fazekas score of 0 and 193 patients with Fazekas score of 3: 6. The results of multivariate Logistic regression showed that there was a significant positive correlation between the aged (G3 vs G1: OR10.81m95 CI 2.7642.38P0.001G4 vs G1:OR 28.4095CI 7.02114.95.P0.05G5 vs G1:OR 68.79-95CI 14.22332.92P0.05), cerebral atherosclerosis (OR 1.9895CI 1.073.65P0.029) and hypertension (OR4.895CI2.658.85) and severe leukoaraiosis (P 0.05). Conclusion Age, atherosclerosis and hypertension may be independent risk factors for severe leukoaraiosis.
【作者单位】：武汉大学中南医院神经内科;
【基金】：国家自然科学基金面上项目(81371273)
【分类号】：R742

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