氟桂利嗪联合丹参多酚酸盐治疗急性偏头痛的临床观察

发布时间：2018-08-13 12:17

【摘要】：目的:观察氟桂利嗪联合丹参多酚酸盐治疗急性偏头痛的疗效和安全性。方法:72例急性偏头痛患者随机分为对照组(36例)和观察组(36例)。在常规治疗的基础上,对照组患者口服盐酸氟桂利嗪胶囊,65岁及以下每晚10 mg,每日1次,65岁以上每晚5 mg,每日1次;观察组患者在对照组治疗的基础上给予注射用丹参多酚酸盐200 mg,静脉滴注,每日1次。两组均连续治疗至痊愈或连续治疗2周。观察两组患者的临床疗效、起效时间、痊愈时间,治疗前后视觉模拟疼痛(VAS)评分、发作频率和持续时间及不良反应发生情况。结果:治疗过程中两组均无患者终止、脱落,均完成治疗。观察组患者总有效率(97.22%)显著高于对照组(86.11%),起效时间、痊愈时间均显著短于对照组,差异均有统计学意义(P0.05)。治疗前,两组患者VAS评分、发作频率、持续时间比较,差异均无统计学意义(P0.05)。治疗后,两组患者VAS评分、发作频率、持续时间均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:在常规治疗的基础上,氟桂利嗪联合丹参多酚酸盐治疗急性偏头痛的疗效与安全性均较好。
[Abstract]:Objective: to observe the efficacy and safety of flunarizine combined with salvia miltiorrhiza polyphenolic acid in the treatment of acute migraine. Methods 72 patients with acute migraine were randomly divided into control group (36 cases) and observation group (36 cases). On the basis of routine treatment, the patients in the control group were treated with flunarizine hydrochloride capsules (10 mg / night) and 5 mg / day (5 mg / day). The patients in the observation group were treated with 200 mg salvia miltiorrhiza polyphenolic acid for injection on the basis of treatment in the control group. Both groups were treated continuously until recovery or 2 weeks of continuous treatment. The clinical efficacy, onset time, recovery time, (VAS) score of visual analogue pain, attack frequency, duration and adverse reactions were observed before and after treatment. Results: in the course of treatment, no patients in both groups were terminated, abscission and treatment was completed. The total effective rate (97.22%) in the observation group was significantly higher than that in the control group (86.11%). The onset time and recovery time were significantly shorter than those in the control group (P0.05). Before treatment, there was no significant difference in VAS score, attack frequency and duration between the two groups (P0.05). After treatment, the VAS score, attack frequency, duration of the two groups were significantly lower than the same group before treatment, and the observation group was significantly lower than the control group, the difference was statistically significant (P0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). Conclusion: flunarizine combined with salvia miltiorrhiza polyphenolic acid is effective and safe in the treatment of acute migraine.
【作者单位】：南华大学附属第二医院临床药学科;南华大学附属第二医院重症医学科;南华大学药学与生命科学院;南华大学附属第二医院药剂科;南华大学附属第二医院内分泌科;
【基金】：湖南省教育厅科学研究项目(No.16C1407)
【分类号】：R747.2

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