低血钙浓度与脑出血患者血肿体积的相关性

发布时间：2018-08-16 07:51

【摘要】：目的探讨低血钙浓度与脑出血患者血肿体积的关系。方法前瞻性连续性纳入2012年1月至2014年10月发病24 h内入住四川大学华西医院神经外科脑出血患者870例,完成血清钙浓度实验室检查和头部CT检查,并收集基线资料及实验室检查结果。根据实验室血钙浓度正常参考值,将患者分为低血钙组(2.1 mmol/L)193例,及正常血钙组(2.1~2.7 mmol/L)677例。采用Spearman相关性分析,分析血钙浓度与患者入院时血肿体积的相关性。结果 (1)低血钙组与正常血钙组比较,男性患者比例高[73.6%(142例)比66.0%(447例)],格拉斯哥昏迷评分中位数分值更低(9分比11分),血肿体积中位数更大(33.86 cm3比21.69 cm3),差异均有统计学意义(均P0.05)。(2)Spearman相关性分析显示,脑出血患者入院时低血钙水平与血肿体积呈弱负相关(r=-0.113,P0.01)。结论该研究提示脑出血患者入院时低血钙浓度男性居多、病情重及血肿体积大,并且低血钙浓度与血肿体积呈潜在负相关性。
[Abstract]:Objective To investigate the relationship between hypocalcemia and hematoma volume in patients with intracerebral hemorrhage.Methods A prospective cohort of 870 patients with intracerebral hemorrhage admitted to the Department of Neurosurgery of West China Hospital of Sichuan University from January 2012 to October 2014 was conducted. According to the normal reference value of serum calcium concentration in laboratory, 193 patients were divided into hypocalcemia group (2.1 mmol/L) and 677 normal serum calcium group (2.1-2.7 mmol/L). Spearman correlation analysis was used to analyze the correlation between serum calcium concentration and hematoma volume at admission. The median score of Glasgow coma score was lower (9 points to 11 points) and the median hematoma volume was larger (33.86 cm 3 to 21.69 cm 3) than 66.0% (447 cases). The difference was statistically significant (all P 0.05). (2) Spearman correlation analysis showed that there was a weak negative correlation between hypocalcemia and hematoma volume at admission in patients with cerebral hemorrhage (r = - 0.113, P 0.01). This study suggests that the majority of patients with cerebral hemorrhage were male with low serum calcium concentration at admission. The condition was severe and the hematoma volume was large.
【作者单位】：四川大学华西医院神经内科;
【分类号】：R743.34

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