血浆低密度脂蛋白与高密度脂蛋白浓度比值和急性脑梗死患者颈动脉粥样硬化斑块稳定性的关系

发布时间：2018-08-20 09:28

【摘要】：目的探讨血浆低密度脂蛋白与高密度脂蛋白浓度比值(plasma low-density lipoprotein/high-density lipoprotein cholesterol concentration ratio,L/H)和急性脑梗死患者颈动脉粥样硬化斑块稳定性的关系。方法根据颈动脉彩色多普勒超声仪检查结果,将138例急性脑梗死患者分为稳定斑块组50例,不稳定斑块组88例,及65例正常对照组。收集一般临床资料及缺血性脑血管病危险因素,测定血脂、糖化血红蛋白、血红蛋白、红细胞分布宽度(red blood cell distribution width,RDW)、血浆纤维蛋白原(fibrinogen,Fib)等并进行比较。结果 (1)与对照组相比,急性脑梗死组TC、LDL-C、L/H、尿酸、RDW、糖化血红蛋白明显增高,差异具有统计学意义(P0.05);(2)不稳定斑块组与对照组相比L/H水平明显升高,具有显著性差异(P0.05)。不稳定组L/H明显高于稳定斑块组,具有显著统计学差异(P0.05);(3)调整性别、年龄因素后,L/H为颈动脉不稳定斑块的危险因素(OR=1.459,95%CI 1.260~1.690,P=0.0010.05)。结论 L/H的增高和颈动脉粥样硬化斑块的不稳定性密切相关。
[Abstract]:Objective to investigate the relationship between plasma low density lipoprotein (LDL) and high density lipoprotein concentration ratio (plasma low-density lipoprotein/high-density lipoprotein cholesterol concentration / L / H) and carotid atherosclerotic plaque stability in patients with acute cerebral infarction. Methods according to the results of carotid color Doppler ultrasound, 138 patients with acute cerebral infarction were divided into stable plaque group (n = 50), unstable plaque group (n = 88) and normal control group (n = 65). General clinical data and risk factors of ischemic cerebrovascular disease were collected, and blood lipids, glycosylated hemoglobin, (red blood cell distribution width of erythrocyte distribution, plasma fibrinogen (Fib) were measured and compared. Results (1) compared with the control group, the levels of L / H, RDW and HbA1c in the acute cerebral infarction group were significantly higher than those in the control group (P0.05). The level of L / H in the unstable plaque group was significantly higher than that in the control group (P0.05). The L / H of unstable plaque group was significantly higher than that of stable plaque group (P0.05); (3). After the age factor, L / H was the risk factor of unstable carotid plaque (ORX 1.459 CI 1.2601.260 P0. 0010.05). Conclusion the increase of L / H is closely related to the instability of carotid atherosclerotic plaque.
【作者单位】：中国医科大学附属第四医院神经内科;
【分类号】：R743.3

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