帕金森病与血管性帕金森综合征患者血清炎症因子的相关性分析

发布时间：2018-08-29 16:12

【摘要】：目的:通过检测帕金森(Parkinson's disease,PD)及血管性帕金森综合征(Vascular parkinsonism,VP)患者外周血清白介素6及白介素32水平,进一步了解炎症因子与患者临床症状的相关性。方法:采用横断面研究,选取2014年10月至2016年10月之间我院门诊及住院部PD患者64例及VP患者48例,对入组患者进行量表评分(UPDRSIII统一帕金森评分量表评分、Hoehn-Yahr分级量表、NMSS帕金森非运动障碍评价量表及MMSE简易智能精神状态检查量表)。同时收集河南科技大学健康体检中心中老年体检者60例。采用ELISA法检测患者及健康体检者外周血清中白介素6及白介素32水平。采用SPSS 21.0软件对对比分析帕金森与血管性帕金森综合征患者两种炎症因子与各量表评分的相关性,P0.05有统计学意义。结果:1.VP患者的发病年龄大于PD患者的发病年龄(F=32.452,P=0.000);VP患者左旋多巴用量高于PD患者(t=2.792,P=0.006);与PD患者相比,VP患者更易出现智能损害(t=2.920,P=0.004);2.PD患者血清白介素6水平显著高于VP患者(P=0.005),且两组患者血清白介素6水平显著高于对照组(P=0.000);VP患者血清白介素32水平显著高于PD患者,且均显著高于对照组(P=0.000);3.PD患者的病程与运动症状评分及左旋多巴用量呈正相关;4.VP患者病程与患者运动等级及智能状态成正相关;5.白介素32水平与PD患者NMSS评分存在正相关关系(r=0.690,P=0.000);6.白介素32水平与VP患者UPDRSIII评分(r=0.511,P=0.000)及Hoehn-Yahr评分(r=0.602,P=0.000)呈正相关。结论:1.两组患者白介素6及白介素32均显著高于对照组;2.白介素6与PD患者及VP患者的临床症状均无关,白介素32与PD患者的非运动症状及VP患者的运动症状均有显著正相关。
[Abstract]:Aim: to investigate the relationship between inflammatory factors and clinical symptoms in patients with Parkinson's disease (Parkinson's disease,PD) and vascular Parkinson's syndrome (Vascular parkinsonism,VP) by detecting the levels of interleukin 6 and interleukin 32 in peripheral blood. Methods: from October 2014 to October 2016, 64 patients with PD and 48 patients with VP were selected by cross-sectional study. The patients were assessed with the UPDRSIII Unified Parkinson's scale (UPDRSIII), including the Hoehn-Yahr scale, the NMSS Parkinson's Non-motor Disorder scale and the MMSE's Mini-Mental State scale. At the same time, we collected 60 cases of middle and old people in the health examination center of Henan University of Science and Technology. The levels of interleukin 6 and interleukin 32 in peripheral serum of patients and healthy persons were detected by ELISA method. SPSS 21.0 software was used to compare and analyze the correlation between the two inflammatory factors and the scores of each scale in patients with Parkinson's syndrome and vascular Parkinson's syndrome (P 0.05). Results: 1. The onset age of VP patients was greater than that of PD patients (F = 32.452P 0.000). The dosage of levodopa in patients with VP was higher than that in patients with PD (t = 2.792 P0. 006). Compared with PD patients, patients with VP were more likely to suffer from intellectual impairment (tn 2.920 P0. 004). 2. The level of interleukin 6 in patients with PD was significantly higher than that in patients with VP. (2) the level of serum interleukin 6 in patients with PD was significantly higher than that in patients with VP. The level of serum interleukin 6 in the two groups was significantly higher than that in the control group (P < 0. 000). The serum level of interleukin 32 in the patients with VP was significantly higher than that in the patients with PD. The course of disease was significantly higher than that of the control group (P0. 000). 3. There was a positive correlation between the course of disease and the score of motor symptom and the dosage of levodopa. 4. There was a positive correlation between the course of disease and the motor grade and intelligence state of the patients with VP. There was a positive correlation between the level of IL 32 and the NMSS score of PD patients (r 0. 690 P 0. 000). The level of interleukin 32 was positively correlated with the UPDRSIII score (r = 0.511) and the Hoehn-Yahr score (r = 0.602) in patients with VP. Conclusion 1. The levels of IL 6 and IL 32 in the two groups were significantly higher than those in the control group. Interleukin-6 was not associated with the clinical symptoms of PD patients and VP patients. Interleukin-32 was positively correlated with non-motor symptoms in PD patients and sports symptoms in VP patients.
【学位授予单位】：河南科技大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R742.5

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