缺血性脑卒中亚型与幽门螺杆菌感染相关性研究

发布时间：2018-08-30 09:47

【摘要】：目的分析缺血性脑卒中亚型与幽门螺杆菌感染相关性,为该病的临床治疗提供指导。方法回顾性分析2016年1-10月期间在本院住院的179例缺血性脑卒中患者(病例组)和同时期193例健康体检者(对照组)幽门螺杆菌感染情况;采用CISS脑卒中分型方法对病例组进行缺血性脑卒中分型,分析缺血性卒中亚型与幽门螺杆菌感染的相关性。结果分析人口统计学特征及临床资料,病例组和对照组患者高血压病史、糖尿病史、吸烟史、家族卒中病史对比的OR值1,性别、生活规律、消化性溃疡病史、高脂血症、教育程度对比的OR值1。病例组幽门螺杆菌感染127例,感染率为70.95%;对照组幽门螺杆菌感染109例,感染率为56.48%。幽门螺杆菌感染可能是缺血性脑卒中患者发病的危险因素(OR值为1.88,95%CI值为1.22~2.89)。采用CISS分型法对缺血性脑卒中进行分型,主要类型为LAA、CS、PAD、OE和UE。其中3种主要亚型LAA型感染90例,感染率为70.87%,OR值为1.65;CS型感染25例,感染率为19.69%,OR值为0.91;PAD感染12例,感染率为9.45%,OR值为0.44。幽门螺杆菌感染可能是LAA型缺血性脑卒中发生的危险因素。结论高血压病史、糖尿病史、吸烟史、家族卒中病史可能增加发生缺血性脑卒中的风险,幽门螺杆菌感染可能是LAA型缺血性脑卒中发生的危险因素。
[Abstract]:Objective to analyze the relationship between subtype of ischemic stroke and Helicobacter pylori infection in order to provide guidance for clinical treatment of ischemic stroke. Methods the infection of Helicobacter pylori in 179 patients with ischemic stroke (case group) and 193 healthy persons (control group) hospitalized in our hospital from January to October 2016 were analyzed retrospectively. The CISS method was used to type ischemic stroke and the correlation between the subtype of ischemic stroke and Helicobacter pylori infection was analyzed. Results the OR values of hypertension, diabetes mellitus, smoking history, family stroke history, sex, life pattern, peptic ulcer history, hyperlipidemia were analyzed. The OR value of educational level contrast is 1. 5%. There were 127 cases of Helicobacter pylori infection in the case group and 109 cases of Helicobacter pylori infection in the control group. Helicobacter pylori infection may be a risk factor for ischemic stroke patients (OR = 1.88 / 95, CI = 1.22 / 2.89). The main types of ischemic stroke were LAA,CS,PAD,OE and UE. by using CISS classification method. Among them, 90 cases were infected with three main subtypes of LAA, the infection rate was 70.87% and the OR value was 1.65%. The infection rate was 19.69% (OR = 0.91%) in 12 cases, and the infection rate was 9.45% (OR = 0.44). Helicobacter pylori infection may be a risk factor for LAA ischemic stroke. Conclusion the history of hypertension, diabetes, smoking and family stroke may increase the risk of ischemic stroke. Helicobacter pylori infection may be the risk factor of LAA ischemic stroke.
【作者单位】：贵州医科大学附属医院;
【基金】：国家自然科学基金项目(No.81460276)
【分类号】：R743.3;R57

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