三维动脉自旋标记成像在缺血性脑梗死患者中的应用研究

发布时间：2018-08-30 09:47

【摘要】：目的分析磁共振三维动脉自旋标记成像(3D-ASL)在急性缺血性脑梗死患者中的应用价值。方法 22例缺血性脑梗死患者行常规MRI序列、DWI、MRA、3D-ASL检查。采集原始数据上传至ADW 4.2工作站,采用Func-tool软件处理,获取灌注参数的伪彩图。观察脑梗死患者的ASL-CBF、DWI图像并分别测量异常灌注面积及梗死面积,分别用Excel表格记录DWI及ASL所测数值,统计数值均以均数±标准差(x±s)表示,采用两独立样本t检验比较两者间的差异;观察MRA梗死区周围的脑血管有无狭窄及闭塞。结果 22例患者中19例ASL显示不同程度灌注异常,19例灌注异常患者的异常灌注部位均与DWI梗死灶一致,ASL-CBF图上灌注异常面积为(17.10±6.15)cm~2,DWI梗死面积为(13.54±4.97)cm~2,ASL-CBF图上灌注异常面积大于DWI图上梗死面积,且差异有统计学意义(P=0.029)。结论 3D-ASL在临床应用中能够较可靠地反映缺血性脑梗死患者的低灌注状态,结合MRA及DWI更有利于指导临床诊疗。
[Abstract]:Objective to analyze the value of magnetic resonance three-dimensional arterial spin-label imaging (3D-ASL) in patients with acute ischemic cerebral infarction. Methods 22 patients with ischemic cerebral infarction were examined by conventional MRI sequence. The original data was uploaded to ADW 4.2 workstation and processed by Func-tool software to obtain pseudo-color images of perfusion parameters. The ASL-CBF,DWI images of patients with cerebral infarction were observed and the abnormal perfusion area and infarct area were measured respectively. The values of DWI and ASL were recorded by Excel tables. The statistical values were expressed as mean 卤standard deviation (x 卤s). Two independent samples t test were used to compare the difference between the two groups and to observe the stenosis and occlusion of cerebral vessels around the infarct area of MRA. Results 19 cases of ASL showed abnormal perfusion in different degree. All the abnormal perfusion sites of 19 cases were consistent with the infarct focus of DWI. The area of abnormal perfusion on ASL-CBF map was (17.10 卤6.15) cm~2,DWI. The area of abnormal perfusion on cm~2,ASL-CBF was (13.54 卤4.97). The area of abnormal perfusion on ASL-CBF was (13.54 卤4.97). Infarct area on DWI, The difference was statistically significant (P0. 029). Conclusion 3D-ASL can reliably reflect the hypoperfusion status of patients with ischemic cerebral infarction in clinical application, and the combination of MRA and DWI is more helpful for clinical diagnosis and treatment.
【作者单位】：徐州医学院附属医院老年科;徐州医学院附属医院影像科;徐州医学院附属医院神经内科;
【分类号】：R743.33

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