阿托伐他汀对急性脑梗死患者颈动脉粥样硬化斑块的影响

发布时间：2018-09-13 11:54

【摘要】：目的探讨阿托伐他汀对急性脑梗死患者颈动脉粥样硬化斑块的影响。方法选自我院于2015年6月~2016年6月期间收治的急性脑梗死患者颈动脉粥样硬化斑块60例,按照随机数字表法分为观察组与对照组各30例。对照组患者给予常规治疗,观察组在对照组基础上结合阿托伐他汀治疗。4周为一个疗程。比较两组患者治疗前后IMT以及血脂各项指标TC、TG、HDL-C、LDL-C的变化情况。结果两组患者治疗前IMT比较差异无统计学意义(P0.05);治疗后,观察组患者的IMT水平为(1.22±0.56)mm,显著低于治疗前及对照组,差异有统计学意义(P0.05)。两组患者治疗前TC、TG、HDL-C、LDL-C比较无统计学差异(P0.05);治疗后,观察组患者的TC为(4.15±1.17)mmol/L、TG为(1.43±0.49)mmol/L、HDL-C为(1.33±0.47)mmol/L、LDL-C水平为(2.39±0.56)mmol/L,与治疗前及对照组分别比较,差异有统计学意义(P0.05)。且观察组患者治疗后的TC、TG、HDL-C、LDL-C较对照组改善更显著(P0.05)。结论阿托伐他汀治疗脑梗死颈动脉粥样硬化不仅可以降低血脂水平,还可以缩小颈动脉粥样硬化斑块,疗效确切,值得临床推广应用。
[Abstract]:Objective to investigate the effect of Atto vastatin on carotid atherosclerotic plaque in patients with acute cerebral infarction. Methods from June 2015 to June 2016, 60 patients with carotid atherosclerotic plaque were randomly divided into two groups: observation group (n = 30) and control group (n = 30). The patients in the control group were treated with routine therapy, and the patients in the observation group were treated with Atto vastatin for a course of 4 weeks on the basis of the control group. The changes of IMT and TC,TG,HDL-C,LDL-C before and after treatment were compared between the two groups. Results there was no significant difference in IMT between the two groups before treatment (P0.05). After treatment, the level of IMT in the observation group was (1.22 卤0.56) mm, significantly lower than that in the control group and before treatment, the difference was statistically significant (P0.05). There was no significant difference in TC,TG,HDL-C,LDL-C between the two groups before treatment (P0.05); after treatment, the TC of the observation group was (4.15 卤1.17) mmol/L,TG (1.43 卤0.49) mmol/L,HDL-C, (1.33 卤0.47) mmol/L,LDL-C and (2.39 卤0.56) mmol/L, the difference was statistically significant (P0.05). The TC,TG,HDL-C,LDL-C in the observation group was significantly better than that in the control group (P0.05). Conclusion Atto vastatin treatment of carotid atherosclerosis in cerebral infarction can not only reduce the level of blood lipid, but also reduce carotid atherosclerotic plaque.
【作者单位】：大连市普兰店区中心医院神经内一科;
【分类号】：R743.33

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