首次脑梗塞患者血清高敏C-反应蛋白、内皮素-1、纤维蛋白原浓度与脑梗塞复发的相关性

发布时间：2018-10-08 10:30

【摘要】：目的 :探讨血清高敏C-反应蛋白(hs-CRP)、内皮素-1(ET-1)及纤维蛋白原(FIB)与首次脑梗塞患者脑梗塞复发的关系。方法 :选取2013年1月~2014年1月,我院收治的首次脑梗塞患者82例,于入院24h内测定血清hs-CRP、ET-1及FIB水平,并随访记录患者的脑梗塞复发情况,采用单因素分析、Logistic多因素回归分析上述指标与脑梗塞复发的关系。结果 :82例患者中22例(26.83%)复发脑梗塞,复发脑梗塞患者的血清hs-CRP、ET-1及FIB水平显著高于未复发组;血清hs-CRP、ET-1及FIB分层分析显示,浓度越高复发率呈显著增高趋势;Logistic相关性分析显示,血清hs-CRP、ET-1及FIB均是脑梗塞复发的独立危险因素。结论 :首次脑梗塞复发患者的脑梗塞复发与血清hs-CRP、ET-1及FIB水平密切相关,高水平血清hs-CRP、ET-1及FIB水平是脑梗塞复发的独立危险因素。
[Abstract]:Objective: to investigate the relationship between serum Gao Min C reactive protein (hs-CRP), endothelin 1 (ET-1) and fibrinogen (FIB) and the recurrence of cerebral infarction in patients with first cerebral infarction. Methods: the serum levels of hs-CRP,ET-1 and FIB were measured in 82 patients with first cerebral infarction from January 2013 to January 2014, and the recurrence of cerebral infarction was recorded. Univariate logistic multivariate regression analysis was used to analyze the relationship between the above indexes and the recurrence of cerebral infarction. Results 22 of 82 patients (26.83%) had recurrent cerebral infarction, and the levels of serum hs-CRP,ET-1 and FIB in patients with recurrent cerebral infarction were significantly higher than those in patients without recurrent cerebral infarction, serum hs-CRP,ET-1 and FIB stratified analysis showed that the higher the recurrence rate was, and the logistic correlation analysis showed that the recurrence rate of recurrent cerebral infarction patients was significantly higher than that of non-recurrent cerebral infarction patients. Serum hs-CRP,ET-1 and FIB were independent risk factors for recurrence of cerebral infarction. Conclusion: the recurrence of cerebral infarction is closely related to the levels of serum hs-CRP,ET-1 and FIB in patients with first cerebral infarction recurrence. The high levels of serum hs-CRP,ET-1 and FIB are independent risk factors for recurrence of cerebral infarction.
【作者单位】：延安大学附属医院;
【分类号】：R743.33

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